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VT-1161

VT-1161 structure

CAS No:
1340593-59-0
Formula:
C23H16F7N5O2
Chemical Name:
VT-1161
Synonyms:
VT-1161;Oteseconazole;UNII-VHH774W97N;VHH774W97N;CHEMBL3311228;(R)-2-(2,4-Difluorophenyl)-1,1-Difluoro-3-(1h-Tetrazol-1-Yl)-1-(5-(4-(2,2,2-Trifluoroethoxy)phenyl)pyridin-2-Yl)propan-2-Ol;Oteseconazole [USAN];Oteseconazole (USAN/INN);SCHEMBL17113021
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51[1][2].

Oteseconazole has been used in trials studying the treatment of Tinea Pedis, Onychomycosis, Candidiasis, Vulvovaginal, and Recurrent Vulvovaginal Candidiasis.

VT-1161 Basic Attributes

Molecular Weight：

527.394

Exact Mass：

527.119202

UNII：

VHH774W97N

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

XLogP3：

5.70

Density：

1.5±0.1 g/cm3

Melting Point：

101 °C

Boiling Point：

609.2±65.0 °C at 760 mmHg

Flash Point：

322.3±34.3 °C

Refractive Index：

1.570

Safety Information

GHS Classification：

|Warning|H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]|P260, P314, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Treatment of vulvovaginal candidiasis

MeSH Entry Terms：

VT-1161

VT-1161 Use and Manufacturing

Use Classification：

Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:527.4
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:8
Exact Mass:527.11922190
Monoisotopic Mass:527.11922190
Topological Polar Surface Area:86
Heavy Atom Count:37
Complexity:743
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of VT-1161

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

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