Dibutyltin dilaurate

631.54900

631.56

201-039-8

1171

2607

2788|3146

DTXSID6024961

Soft crystals or yellow liquid|Oily liquid

29319090

52.60000

10.95700

yellow liquid

1.05 g/cm³ @ Temp: 20 °C

22-24 °C

205 °C @ Press: 9.8 Torr

226ºC

n20/D 1.471(lit.)

H2O: <0.1 g/100 mL at 20 ºC

0.2 mm Hg ( 160 °C)

21.8 (NTP, 1992) (Relative to Air)|21.8 (Air = 1)

LD50 orally in Rabbit: 175 mg/kg

This compound may be sensitive to air or heat. (NTP, 1992). Insoluble in water.

Salts, Basic

DIBUTYLTIN DILAURATE is strongly reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents.

III

6.1

UN 2922

3

R22; R26; R36/38; R50/53

S26-S28-S36/37-S45-S60-S61

WH7000000

T+; N

Stability Combustible. Incompatible with strong oxidizing agents. May be air sensitive.

P201-P260-P273-P280-P305 + P351 + P338-P310

H314-H317-H341-H360-H370-H372-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

... Reacts with oxidizers.

Dibutyltin dilaurate is an indirect food additive for use only as a catalyst for polyurethane resins as a component of adhesives.

This chemical is combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]|P201, P202, P260, P264, P270, P281, P308+P313, P314, P405, and P501|H301 (14.29%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P322, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P405, and P501|Aggregated GHS information provided by 1505 companies from 98 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P314, P321, P333+P313, P363, P391, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P201, P202, P260, P264, P270, P271, P280, P281, P284, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P314, P320, P321, P363, P403+P233, P405, and P501|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P271, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P314, P320, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501

Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)|Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Combustible when exposed to heat or flame; reacts with oxidizers.

Avoid the vapor produced by heating.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

... /Dibutyltin dilaurate/ may cause skin or eye irritation by contact ... .

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Store in an area without drain or sewer access.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is irritating to the eyes and skin.

The substance may have effects on the liver, kidneys, gastrointestinal tract and immune system. May cause toxicity to human reproduction or development. May cause heritable genetic damage to human germ cells.

NO open flames.

AVOID ALL CONTACT!

Use ventilation.

Protective gloves.

Wear safety spectacles.

The concn of dibutyltin in the effluent of five municipal sewage treatment plants in Germany ranged from 3-48 ng Sn/l while that of a producer of organotin compounds was 8570 ng Sn/l(1).

SEDIMENT: The only monitoring data located were for dibutyltin (Bu2Sn++) without regard for the identity of the accompanying anion(s) and concn was reported in Sn equivalents(1). Dibutyltin was detected and quantified in 61 of 235 samples of the top 2 cm of sediment from bodies of surface water in Canada sampled between 1982-1985 at concentrations ranging from 0.01 to 8.51 ppm Sn (dry wt) (average concn of pos, quantified samples = 0.49 ppm Sn (dry wt); dibutyltin also was detected, not quantified in another 27 of the samples (concn range from approx >3.3 ppb Sn (dry wt) (limit of detection) to <0.01 ppm Sn (dry wt) (limit of quantitation))(1). Dibutyltin was not detected in sediment from one site in Michigan and six sites in New York state(1).|SEDIMENT: The concentration of dibutyltin species in sediment (upper 2 cm) from Toronto Harbor (5 sites) was 0.01-0.26 mg Sn/kg dry weight(1). The concn of dibutyltin in sediment from two harbors along the Rhine River in Germany were 44 and 15 ng Sn/g dry wt; the high level is from a small harbor that is crowded with pleasure crafts that are believed to be responsible for large releases of tributyltin(2). Sediment from a tributary of the Rhine with a high input of sewage contained 477 ng Sn/g dry wt(2). Intertidal sediments at a restricted site downstream from the shipyards in the Sado estuary, Portugal reached levels of 9600 ng/g dry wt for dibutyltin in July samples, over an order of a magnitude higher than samples taken in March(3). This has been ascribed to the cleaning of ships in spring and points up the large seasonal variability in organotin levels. Fluvial, intertidal, and marine levels of dibutyltin at other sites in the Sado Estuary were 7.5-85, 5.0-57, and 10-50 ng/g, respectively.

LD50 Rat male oral 175 mg/kg (oil solution)|LD50 Rat intraperitoneal 85 mg/kg|Irritant dose rabbit dermal 500 mg/24 hr; irritant effects: moderate skin irritation|Irritant dose rabbit ocular 100 mg/24 hr; irritant effects: moderate eye irritation

Dibutyltin dilaurate's production and use as a stabilizer for vinyl resins, poly(vinyl chloride), lacquers, and elastomers, and as a catalyst for polyurethanes and silicones(1) may result in its release to the environment through various waste streams(SRC). Dibutyltin is formed as a degradation product of tributyltin, an antifouling agent used in marine paint(2).

The final degradation products of organotins are believed to consist of inorganic salts. /Organotin compounds/|TERRESTRIAL FATE: Dibutyltin dilaurate is expected to dissociate in soil forming the cation, dibutyltin(SRC). Dibutyltin is expected to adsorb to organic carbon and clay(SRC). Volatilization from moist soil surfaces is not expected to be an important fate process because the cation is not expected to volatilize(SRC). Dibutyltin dilaurate may also biodegrade in soil, since tributyltins are converted to dibutyltin and monobutyltin(1).|AQUATIC FATE: Dibutyltin dilaurate is expected to dissociate in water forming the cation, dibutyltin(SRC). Cations generally adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected to be an important fate process because the cation is not expected to volatilize(SRC). Dibutyltin dilaurate may also biodegrade in soil(1). According to a classification scheme(2), a BCF value of 31(3) suggests the potential for bioconcentration in aquatic organisms is low(SRC). Tributyltin species in water are sequentially degraded to dibutyltin, monobutyltin, and finally to inorganic tin in water/sediment mixtures or water alone from Toronto Harbor, Canada(4). Small quantities of dimethyldibutyltin were occasionally detected in these experiments in water/sediment and water alone, but not in the sterile controls, which indicates the possibility of biomethylation of dibutyltin compounds(4).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dibutyltin dilaurate, which has an estimated vapor pressure of 4.5X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase dibutyltin dilaurate may be removed from the air by wet and dry deposition(SRC).

Dibutyltin compounds such as dibutyltin dilaurate in environmental waters probably either exist as or will rapidly be converted to dibutyltin oxides, hydroxides, carbonates, or hydrated cations(3). Dibutyltin cation may react with water and behave like a simple protic acid due to the resulting formation of hydronium ion and either dibutyltin dihydroxide or other dibutyltin-hydroxide species at concn above approx 1X10-5 M, based upon the behavior of dimethyltin dication(2). In seawater, the chloride ion may compete effectively with hydroxide ions and stabilize the presence of mono-n-butyltin trichloride in solution(2). Dissociation and speciation of dibutyltin dilaurate in the environment may affect its fate and transport processes(SRC). Dibutyltin compounds may react with sulfides present in sediment, leading to the formation of dibutyltin sulfide(3). Dibutyltins are degraded by UV radiation yielding inorganic tin as a final product(1). Dibutyltin dilaurate may be susceptible to photooxidation by photochemically produced hydroxyl radicals in the atmosphere(SRC).

The observed BCF for dibutyltin dilaurate in round crucian carp (Carassius carassius grandoculis) muscle, vertebra, liver, and kidney tissue were 31, 54, 813, and 138, respectively(1). According to a classification scheme(2), a BCF value of 31(1) suggests bioconcentration in aquatic organisms is low(SRC).

Dibutyltin dilaurate is expected to hydrolyze in water forming the cation, dibutyltin(SRC). Cations generally adsorb to organic carbon and clay; therefore, dibutyltin may be expected to have limited mobility in soil(SRC). In a 278-day marine mesocosm experiment in which tributyltin was added to the system in summer, the distribution coefficient for dibutyltin between the dissolved state and particulate matter calculated from data between days 2-19 was 30,000 (standard deviation 20,000)(1). Other investigators obtained distribution constants for adsorption of dibutyltin to particulate matter and sediment of 600 l/kg and 700-26,000 l/kg, respectively; values were a function of sediment type and location(1). The Freundlich parameters, log k and 1/n, for dibutyl tin to sediment was 1.33 and 0.969, respectively(2). In a study of desorption from sediment, approximately 1% of the initial dibutyltin species was observed to desorb from the unshaken Toronto Harbor sediment/water mixtures in 10.6 months(3).

Dibutyltin dilaurate is expected to dissociate in water forming the cation, dibutyltin(SRC). Volatilization from moist soil and water surfaces is not expected to be an important fate process because the cation is not expected to volatilize(SRC). Dibutyltin dilaurate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.5X10-9 mm Hg(SRC), determined from a fragment constant method(1).

SURFACE WATER: The only monitoring data located were for dibutyltin (Bu2Sn++) without regard for the identity of the accompanying anion(s) and concn is often reported in Sn equivalents(1). Dibutyltin was detected and quantified in 26 of 214 samples of unfiltered subsurface water from 209 locations in Canada sampled between 1982- 1985 at concentrations ranging from 0.01 to 1.36 ppb Sn (average concn of pos, quantified samples = 0.12 ppb Sn); dibutyltin also was detected, not quantified in another 21 of the samples (concn range from approx 3.3 parts/trillion Sn (limit of detection) to <0.01 ppb Sn (limit of quantitation))(1). Dibutyltin was detected at one of six sites in New York state at 0.01 ppb Sn, but was not detected in one sample from the Detroit River, MI(1).|SURFACE WATER: The concentration of dibutyltin species in unfiltered subsurface water from Toronto Harbor (7 sites) was trace-0.10 ug Sn/l(1). Dibutyl tin was found in unfiltered subsurface water and unfiltered surface microlayers of various lakes, rivers, and harbors in Ontario at levels ranging from 0.01-7.30 and 0.71-2600 ug/l, respectively, indicating that this species was concentrated by factors of up to 4 orders of magnitude in the microlayer(2). Water samples taken over several months in the Rhine River at Mainz in 1989 reported dibutyltin levels of 0.5-2 ng Sn/l in 13 of 14 samples taken(3). In 4 harbors at Mainz and Wiesbaden, they ranged from 1-16 ng Sn/l. In the Schwarzbach, a tributary of the Rhine near Mainz, dibutyltin levels were 2 ng Sn/l, only slightly lower than that in the effluent of sewage treatment plants(3). This is consistent with the very high input of sewage in this stream. Dibutyltin concns ranged from 13-30 ng Sn/l and 1.6 to 67 ng Sn/l on the Elizabeth River (10 locations) and Sarah Creek (8 locations), both rivers feeding into the lower Chesapeake Bay(3).|SURFACE WATER: The only monitoring data located were for dibutyltin (Bu2Sn++) without regard for the identity of the accompanying anion(s) and concn is often reported in Sn equivalents(1). Dibutyltin was detected and quantified in samples of unfiltered subsurface water from 5 of 6 sites in Toronto Harbor, Ontario at concn ranging from 0.01 to 0.10 ppb Sn (avg concn was 0.04 ppb Sn), and it was detected, not quantified, in the other site in the harbor; dibutyltin was detected, not quantified, in water from 1 of 2 sites outside the harbor(1).|SURFACE WATER: The only monitoring data located were for dibutyltin (Bu2Sn++) without regard for the identity of the accompanying anion(s)(1). Analysis for dibutyltin in samples of unfiltered surface microlayer and subsurface water from Maryland waters of Chesapeake Bay sampled approx monthly between July 1985 to June 1986, gave the following results: four marinas, microlayer, 32 of 44 samples pos, 0.033 to 1.156 ppb, 0.25 ppb avg; subsurface 36 of 48 samples pos, 0.010 to 0.298 ppb, 0.080 ppb avg; Baltimore Harbor, microlayer, 3 of 6 samples pos, 0.017 to 0.035 ppb, 0.026 ppb avg; subsurface, 5 of 12 pos, 0.016 to 0.035 ppb, 0.026 ppb avg; Chesapeake and Delaware Canal (a major shipping canal), microlayer, 3 of 6 samples pos, 0.022 to 1.1 ppb, 0.40 ppb avg; subsurface, 3 of 12 pos, 0.012 to 0.016 ppb; Potomac and Choptank Rivers, microlayer, 1 of 11 pos, 0.029 ppb; subsurface, 3 of 24 pos, 0.020 to 0.022 ppb(1).|SURFACE WATER: The only monitoring data located were for dibutyltin (Bu2Sn++) without regard for the identity of the accompanying anion(s)(1). Dibutyltin was detected in unfiltered surface and bottom water from San Diego Harbor in 28 of 32 samples taken in 1983 through 1985 from 5 stations at concn ranging from 0.01 to 0.46 ppb (0.12 avg concn)(1).

In a survey of Canadian wines from 3 provinces, dibutyltin was the predominant butyltin present, with 23.2% of samples tested containing 1.1-138.1 ng/ml. The source of butyltin was not reported(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 89,107 are potentially exposed to dibutyltin dilaurate in the USA(1). Occupational exposure to dibutyltin dilaurate may occur through dermal contact with this compound at workplaces where dibutyltin dilaurate is produced or used(SRC). Monitoring data indicate that the general population may be exposed to dibutyltin via ingestion of food and drinking water, but this may or may not be due to the dilaurate(SRC).

Anthelmintics; Coccidiostats|MEDICATION (VET): Dibutyltin dilaurate (Polystat, Tinostat) is added to feed to remove cecal worms, roundworms, & tapeworms in turkeys to prevent hexamitosis & coccidiosis. The dose ranges between 200 & 1400 ppm.|Anthelmintic

... Rats fed dibutyltin dilaurate at a dose of 17.5 mg/kg per day for 15 days by oral intubation exhibited a 15% stimulation of heme oxygenase activity and a decreased hepatocellular cytochrome p450 content. These effects were accompanied by a decrease in the specific activities of several microsomal enzymes. In addition, pentobarbital-induced sleeping time was increased in proportion to the duration of the dibutyltin exposure, demonstrating the impairment of barbiturate metabolism in the dibutyltin-treated animals.

SYMPTOMS: Symptoms associated with this compound include primary skin irritation, nausea, headache, muscular weakness and paralysis. ACUTE/CHRONIC HAZARDS: This compound may cause skin irritation on contact. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Butynorate

The substance can be absorbed into the body by ingestion and through the skin.

Redness. MAY BE ABSORBED!

Redness.

Adhesive manufacturing|Dodecanoic acid, 1,1'-(dibutylstannylene) ester: ACTIVE