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Metformin hydrochloride

Metformin hydrochloride structure

CAS No:
1115-70-4
Formula:
C4H11N5.ClH
Chemical Name:
Metformin hydrochloride
Synonyms:
Imidodicarbonimidic diamide,N,N-dimethyl-,hydrochloride (1:1);Biguanide,1,1-dimethyl-,monohydrochloride;Imidodicarbonimidic diamide,N,N-dimethyl-,monohydrochloride;Biguanide,1,1-dimethyl-,hydrochloride;Metformin hydrochloride;N,N-Dimethylbiguanide hydrochloride;1,1-Dimethylbiguanide hydrochloride;Meguan;N1,N1-Dimethylbiguanide hydrochloride;Diabefagos;Glucophage;Glyformin;LA 6023;Dabex;Denkaform;Dextin;Diabetmin;Diabex;Apophage;Benofomin;Diformin Retard;Dimefor;Fornidd;Geamet;Glucaminol;Glucofago;Glucomet;Glucomine;Glucoform;Glucomin;Gluconil;Glucophage 850;Glucophage Forte;Glucophage-Mite;Glucophage Retard;Gludepatic;Glufor;Gluformin;Glumeformin;Glumin;Glupermin;Glyciphage;Glycon;Metforal;Metomin;Miformin;Orabet;Siamformet;Walaphage;Diaformin;Diformin;Glyceriphage;Diabetosan;Dialon;Glucophage XR;N,N-Dimethylbiguanidinium chloride;Apo-Metformin;Brot;Glumetza;Glifage;Glucophage SR;Melbin;N,N-Dimethylbiguanidine monohydrochloride;Glucoformin;Riomet;Glumin XR;Metgluco;Neodipa;Diabetmim;FORTAMET;Obimat-SR;15537-72-1;56258-19-6;144377-16-2
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Metformin (hydrochloride) is an FDA approved first-line drug for the treatment of type 2 diabetes. Metformin decreases hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory-chain complex 1.

Metformin hydrochloride Basic Attributes

Molecular Weight：

165.62500

Exact Mass：

165.07800

EC Number：

605-006-2

HScode：

2925290090

Characteristics

PSA：

88.99000

XLogP3：

1.05850

Appearance：

crystalline solid

Melting Point：

232 °C

Boiling Point：

224.1ºC at 760 mmHg

Flash Point：

89.3ºC

Water Solubility：

In water, 1.06X10+6 mg/L (miscible) at 25 deg C (est)

Storage Conditions：

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 deg C. Storage class (TRGS 510): Non Combustible Solids. /Metformin hydrochloride/

Vapor Pressure：

0.0929mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22; R36/38

safety instructions：

S26-S36

RTECS Number：

DU1800000

Marks：

Stability/Shelf Life：

Stable under recommended storage conditions. /Metformin hydrochloride/

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H315-H319

Metformin hydrochloride Use and Manufacturing

Methods of Manufacturing

500mg of metformin free base was dissolved in 3Om^ of acetone, and then 280^ of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then Was charged into a 300 L autoclave100kg of dicyandiamide and 120kg of dimethylamine hydrochloride were added, and 300kg of cyclohexanol was added. The stirring speed was 45r / min, the vacuum degree of the reaction kettle was adjusted to 0.08MPa, heated to 140 and reacted for 3h. And the crude product is recrystallized with ethanol, filtered and dried to obtain metformin hydrochloride.1, 000 Kg of diphenyl ether was charged into the reaction tank, and 250 kg of dimethylamine hydrochloride and 240 kg of dicyandiamide were uniformly added thereto while stirring.After the feeding is completed, the temperature of the reaction tank is raised to 195-200°C, and the temperature is maintained for 1 hour. Insulation is completed, slowly cooled to about 50 °C and filtered, washed twice with isoamyl alcohol 250Kg at 100 °C, and dried at 130-135 °C.The crude product was recrystallized with 95percent ethanol, the amount of ethanol was about 3 times that of the crude product, and the mixture was stirred and heated to reflux so that the crude product was completely dissolved, naturally cooled to room temperature, and allowed to stand for 5 hours.White needle-like crystals were precipitated, filtered, and dried at 100°C for 12 hours to obtain 418.7 kg of metformin hydrochloride, a purity of 99.79percent, and a dicyandiamide content of less than 0.005percent (a Pharmacopoeia limit of ≤ 0.04).1 Kg of 2-cyanoguanidine and 1.15 Kg of Dimethyl amine hydrochloride were added to 2 Kg of n-butanol in a 5 L glass flask. The flask was equipped withcooling water condenser and the flask was allowed to reflux for 22 h. The resulting reaction mass was cooled to ambient temperature, preferably 10-110°C and filtered. Dried the obtained solid at 50°75°C, to get Pure Metformin hydrochloride (1.9 Kg)

Uses

1. An oral hypoglycemic agent
2. Anti-diabetic and anti-cancer activity

Computed Properties

Molecular Weight:165.62
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:165.0781231
Monoisotopic Mass:165.0781231
Topological Polar Surface Area:91.5
Heavy Atom Count:10
Complexity:132
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Price Analysis

Make your Metformin hydrochloride purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Metformin hydrochloride prices .

Drug Function and Efficacy

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: 1. Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization; 2. Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc.; 3. Inhibit hepatic gluconeogenesis and reduce hepatic glucose output; 4. Inhibit intestinal wall cells from taking up glucose; 5. Inhibit the biosynthesis and storage of cholesterol and reduce blood triglyceride and total cholesterol levels. Unlike the effect of insulin, this product has no effect on promoting fat synthesis and no obvious hypoglycemic effect on normal people, but has a good therapeutic effect on type 2 diabetes.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Metformin Hydrochloride Extended Release Tablets
Ingredients	1,1-Dimethylbiguanide hydrochloride
Indication	1. When used in combination with insulin, the hypoglycemic effect is enhanced, and the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin, etc.), which may cause bleeding tendency. 3. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dosage of this product should be reduced. 4. Furosemide increases the serum and whole blood drug concentrations of metformin, but does not change the renal clearance rate of metformin. 5. Nifedipine can increase the absorption of metformin and increase the excretion in urine, but does not affect Tmax and half-life.
Specifications	0.5g
Manufacturer	Beijing Wanhui Double-Crane Pharmaceutical Company Limited

Metformin Hydrochloride Extended Release Tablets
Ingredients	1,1-Dimethylbiguanide hydrochloride
Indication	1. When used in combination with insulin, the hypoglycemic effect is enhanced, and the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin, etc.), which may cause bleeding tendency. 3. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dosage of this product should be reduced. 4. Furosemide increases the serum and whole blood drug concentrations of metformin, but does not change the renal clearance rate of metformin. 5. Nifedipine can increase the absorption of metformin and increase the excretion in urine, but does not affect Tmax and half-life.
Specifications	0.5g
Manufacturer	Beijing Wanhui Double-Crane Pharmaceutical Company Limited

Metformin Hydrochloride Extended Release Tablets
Ingredients	1,1-Dimethylbiguanide hydrochloride
Indication	1. When used in combination with insulin, the hypoglycemic effect is enhanced, and the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin, etc.), which may cause bleeding tendency. 3. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dosage of this product should be reduced. 4. Furosemide increases the serum and whole blood drug concentrations of metformin, but does not change the renal clearance rate of metformin. 5. Nifedipine can increase the absorption of metformin and increase the excretion in urine, but does not affect Tmax and half-life.
Specifications	0.5g
Manufacturer	Beijing Wanhui Double-Crane Pharmaceutical Company Limited

See More Related Drugs

Registered Holders

MERCK SANTE SAS

United States
Active
Uquifa Mexico, S.A. de C.V.

Japan
Active
Farmhispania S.A.

Japan
Active

See More Registered Holders

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