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Strontium ranelate

Strontium ranelate structure

CAS No:
135459-87-9
Formula:
C12H10N2O8S.2Sr
Chemical Name:
Strontium ranelate
Synonyms:
3-Thiopheneacetic acid,5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-,strontium salt (1:2);S 12911;Strontium ranelate;Protos;S 12911-2;Protelos;Distrontium renelate;Bivalos;Osseor;Strometta
Categories:
Organic Chemistry > Organometallic Compounds

Description

Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased

Strontium ranelate Basic Attributes

Molecular Weight：

513.49000

Exact Mass：

513.79600

UNII：

391RT5Q293

DSSTox ID：

DTXSID7046918

ATC Code：

M05BX03|M - Musculo-skeletal system

HScode：

2942000000

Characteristics

PSA：

160.47000

Density：

1.8±0.1 g/cm3

Melting Point：

>310°C (dec.)

Boiling Point：

778.8ºC at 760 mmHg

Flash Point：

424.8ºC

Refractive Index：

1.695

Water Solubility：

H2O: soluble 1mg/mL, clear (warmed)

Safety Information

Transport codes：

3077

hazard class code：

20/21/22

safety instructions：

36/37

RTECS Number：

XM7581000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302 + H312 + H332

GHS Classification：

|Warning|H302+H312+H332 (95.24%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 42 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]|P201, P260, P263, P264, P270, and P308+P313|Aggregated GHS information provided by 52 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Treatment of severe osteoporosis in postmenopausal women at high risk for fracture to reduce the risk of vertebral and hip fractures., , Treatment of severe osteoporosis in adult men at increased risk of fracture., , The decision to prescribe strontium ranelate should be based on an assessment of the individual patient's overall risks.,|Treatment of osteoporosis|Osteoporosis

MeSH：

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

MeSH Entry Terms：

3-(3-cyano-4-carboxymethyl-5-carboxy-2-thienyl)-3-azapentanedioic distrontium salt

Strontium ranelate Use and Manufacturing

Uses

Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic

Use Classification：

Human drugs -> Osseor -> EMA Drug Category|Drugs for treatment of bone diseases -> Human pharmacotherapeutic group|Human drugs -> Protelos -> EMA Drug Category|Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:639.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:4
Exact Mass:639.8696636
Monoisotopic Mass:639.8696636
Topological Polar Surface Area:223
Heavy Atom Count:32
Complexity:533
Covalently-Bonded Unit Count:10
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific description provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Strontium ranelate dry suspension

Strontium ranelate dry suspension
Ingredients	The main ingredient of this product is strontium ranelate.
Indication	When aluminum hydroxide and magnesium hydroxide are taken 2 hours before or at the same time as strontium ranelate, the absorption of strontium ranelate is slightly reduced (AUC is reduced by 20-25%), but when antacids are taken 2 hours after strontium ranelate, the absorption is almost unaffected, so it is best to take antacids 2 hours after taking strontium ranelate. However, when the recommended dosing method is not feasible due to the recommendation to take strontium ranelate before bedtime, taking it at the same time is still acceptable.
Specifications	2 g

Strontium ranelate dry suspension
Ingredients	The main ingredient of this product is strontium ranelate.
Indication	When aluminum hydroxide and magnesium hydroxide are taken 2 hours before or at the same time as strontium ranelate, the absorption of strontium ranelate is slightly reduced (AUC is reduced by 20-25%), but when antacids are taken 2 hours after strontium ranelate, the absorption is almost unaffected, so it is best to take antacids 2 hours after taking strontium ranelate. However, when the recommended dosing method is not feasible due to the recommendation to take strontium ranelate before bedtime, taking it at the same time is still acceptable.
Specifications	2 g

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