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Citalopram hydrobromide

Citalopram hydrobromide structure

CAS No:
59729-32-7
Formula:
C20H21FN2O.BrH
Chemical Name:
Citalopram hydrobromide
Synonyms:
5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-,hydrobromide (1:1);5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-,monohydrobromide;Citalopram hydrobromide;Seropram;Cipramil;Celexa;Cipram;Lupram;Apertia;Sepram;Lu 10-171B;Elopram;Prisdal;(±)-Citalopram hydrobromide;Lecital;S-Pram;Pramcit;Cheer;Citopram;[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-isobenzofuran-5-carbonitrile hydrobromide;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has US FDA approval to treat major depression.

A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.

Citalopram hydrobromide Basic Attributes

Molecular Weight：

405.30400

Exact Mass：

404.09000

EC Number：

261-890-6

NSC Number：

758684

DSSTox ID：

DTXSID40872344

HScode：

2932999099

Characteristics

PSA：

36.26000

XLogP3：

4.77108

Appearance：

White Crystalline Powder

Melting Point：

182-183 °C

Boiling Point：

182-188ºC

Flash Point：

212.8ºC

Water Solubility：

Sparingly soluble in water and soluble in ethanol.

Storage Conditions：

-20ºC Freezer

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3249

wgk germany：

hazard class code：

11-23/24/25-39/23/24/25

safety instructions：

7-16-36/37-45

RTECS Number：

NP6313500

Marks：

F,T

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (96.49%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 114 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)|Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Serotonin Uptake Inhibitors.)

MeSH Entry Terms：

Celexa

Citalopram hydrobromide Use and Manufacturing

Methods of Manufacturing

10g citalopram was heated and dissolved in 40mL isopropanol. After cooled down, pH of the solution was adjusted to 6-7 with bromic acid. The mixture was disposed with active carbon and filtrated, cooled down and placed aside to crystallize. Then the solution was filtrated and washed to give citalopram hydrobromic salt crystal. The obtained salt crystal was recrystallized to give 9.82g citalopram hydrobromic salt crystal with the yield of 88.2percent and the purity of 99.9percent (HPLC, area normalization method).

Uses

An inhibitor of serotonin (5-HT) uptake. Used as an antidepressant.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:405.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:404.08995
Monoisotopic Mass:404.08995
Topological Polar Surface Area:36.3
Heavy Atom Count:25
Complexity:466
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. It is a strong and selective 5-HT uptake inhibitor with antidepressant effect. 2. It has no inhibitory effect on cholinergic muscarinic receptors, histamine receptors and α-adrenergic receptors, reducing common side effects such as dry mouth, sedation, postural hypotension, etc. 3. It is equally effective for patients with endogenous and non-endogenous depression, and the antidepressant effect is usually established after 2-4 weeks. 4. It does not affect the cardiac conduction system and blood pressure, and is suitable for elderly patients. 5. It does not cause weight gain or enhance the effects of alcohol, and is suitable for long-term treatment.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Citalopram Hydrobromide
Ingredients	Chemical name: 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, hydrobromide Molecular weight: C20H22BrFN2O
Indication	This product cannot be taken with monoamine oxidase inhibitors (such as isocarboxazid and moclobemide used to treat depression, and propranolol hydrochloride used to treat Parkinson's disease), otherwise it will cause serious adverse reactions. 1. The interval between the use of this product and monoamine oxidase inhibitors should be more than 14 days. However, if a reversible monoamine oxidase inhibitor with a short half-life is used, such as moclobemide (half-life of 1 to 2 hours), it can be used one day after stopping the medication. 2. Central nervous system drugs-Since citalopram mainly acts on the central nervous system, it should be used with caution when used in combination with other drugs that act on the central nervous system. Alcohol-Although citalopram did not enhance the effects of alcohol on sensory and motor nerves in clinical trials, like other drugs for the treatment of mental illness, it is recommended that patients with depression taking citalopram do not

Citalopram Hydrobromide

Ingredients

Chemical name: 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, hydrobromide Molecular weight: C20H22BrFN2O

Indication

This product cannot be taken with monoamine oxidase inhibitors (such as isocarboxazid and moclobemide used to treat depression, and propranolol hydrochloride used to treat Parkinson's disease), otherwise it will cause serious adverse reactions. 1. The interval between the use of this product and monoamine oxidase inhibitors should be more than 14 days. However, if a reversible monoamine oxidase inhibitor with a short half-life is used, such as moclobemide (half-life of 1 to 2 hours), it can be used one day after stopping the medication. 2. Central nervous system drugs-Since citalopram mainly acts on the central nervous system, it should be used with caution when used in combination with other drugs that act on the central nervous system. Alcohol-Although citalopram did not enhance the effects of alcohol on sensory and motor nerves in clinical trials, like other drugs for the treatment of mental illness, it is recommended that patients with depression taking citalopram do not

Citalopram Hydrobromide Tablets
Ingredients	The main ingredient of this product is Citalopram hydrobromide, chemical name: 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, hydrobromide.
Indication	Concomitant use of monoamine oxidase inhibitors may result in hypertensive crisis.
Specifications	20 mg

Citalopram Hydrobromide

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Registered Holders

RAKS PHARMA PVT LTD

United States
Active
VIRUPAKSHA ORGANICS LTD

United States
Active
JUBILANT BIOSYS LTD

United States
Active

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