Dipotassium glycyrrhizinate
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Dipotassium glycyrrhizinate
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CAS No:
68797-35-3
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Formula:
C42H62O16.2K
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Chemical Name:
Dipotassium glycyrrhizinate
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Synonyms:
α-D-Glucopyranosiduronic acid,(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-,potassium salt (1:2);α-D-Glucopyranosiduronic acid,(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-,dipotassium salt;30-Noroleanane,α-D-glucopyranosiduronic acid deriv.;Dipotassium glycyrrhizate;Glycyrrhizinic acid dipotassium salt;Glycyrrhizic acid dipotassium salt;Dipotassium glycyrrhizinate;18β-Glycyrrhizic acid dipotassium salt;Glycyrrhizin dipotassium salt;Licozin G 1;OriStar DPG;Glycyrrhizinate dipotassium;79165-05-2
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CAS No:
Description
Dipotassium glycyrrhizinate is a natural compound, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity[1].
Glycyrrhizinate dipotassium is an organic molecular entity.|A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
Acid, Glycyrrhizic
Dipotassium glycyrrhizinate Use and Manufacturing
Dipotassium Glycyrrhizinate is used in improving the dissolution property of amphotericin B (AMB) and the bioavailability of the drug incorporated in suppositories.
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, potassium salt (1:2): ACTIVE
Cosmetics -> Humectant; Skin conditioning
Computed Properties
Molecular Weight:899.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:5
Exact Mass:898.3155488
Monoisotopic Mass:898.3155488
Topological Polar Surface Area:273
Heavy Atom Count:60
Complexity:1720
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Naphtholine is an adrenergic drug that can cause vasoconstriction and relieve congestion. Chlorpheniramine has a strong antihistamine effect and can relieve eye allergy symptoms. Vitamin B6 is an indispensable substance in the metabolism of amino acids and fats in the body. Vitamin B6 deficiency can cause vascular congestion, hyperkeratosis, loss of eyelid hair, and corneal neovascularization. Neostigmine is an anticholinesterase drug that inhibits cholinesterase activity, strengthens and prolongs the physiological effects of acetylcholine, enhances the excitability of eye smooth muscles and extraocular muscles, and improves contractility. This product can improve the eye's regulatory function and eliminate eye fatigue caused by long-term use of the eyes or other reasons. It also has the effect of reducing conjunctival congestion.
Registered Holders
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XinjiangTianshan Pharmaceutical Ind. Co., Ltd.
Active
China
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Gansu Tianyu Biological Pharmaceutical Limited Liability Company
Inactive
China
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Shaanxi Fujie Pharmaceutical Co., Ltd.
Inactive
China
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