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Sibutramine hydrochloride

Sibutramine hydrochloride structure

Sibutramine hydrochloride 

structure
  • CAS No:

    84485-00-7

  • Formula:

    C17H26ClN.ClH

  • Chemical Name:

    Sibutramine hydrochloride

  • Synonyms:

    Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-,hydrochloride (1:1);Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-,hydrochloride;Sibutramine hydrochloride;BTS 54524;Reductil;Vazy;Redulip;111394-01-5

  • Categories:

    Active Pharmaceutical Ingredients  >  Nervous System Drugs

Sibutramine hydrochloride Basic Attributes

316.31

279.175385

758928

DTXSID4045927

2921519090

Characteristics

3.2

5.73 (est)

1.0±0.1 g/cm3

190-200°C

342.6±25.0 °C at 760 mmHg

161.0±23.2 °C

1.530

<0.7 [ug/mL]

Store at RT

1.14X10-4 mm Hg at 25 deg C (est)

168 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Drug Information

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)|Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

(R)-DDMS

Sibutramine hydrochloride Use and Manufacturing

Uses

Used as an antidepressant

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:316.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:315.1520553
Monoisotopic Mass:315.1520553
Topological Polar Surface Area:3.2
Heavy Atom Count:20
Complexity:275
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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