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Levofloxacin hydrochloride

Levofloxacin hydrochloride structure

CAS No:
177325-13-2
Formula:
C18H20FN3O4.ClH
Chemical Name:
Levofloxacin hydrochloride
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride (1:1),(3S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride,(S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride,(3S)-;Levofloxacin hydrochloride;Weilisu;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
Categories:
Pharmaceutical Intermediates > Antibacterials

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Levofloxacin hydrochloride Basic Attributes

Molecular Weight：

397.83

Exact Mass：

397.120453

EC Number：

605-797-4

HScode：

29349990

Characteristics

PSA：

73.3

XLogP3：

2.34890

Boiling Point：

571.5°C at 760 mmHg

Flash Point：

299.4ºC

Vapor Pressure：

6.7E-14mmHg at 25°C

Price Analysis

Make your Levofloxacin hydrochloride purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Levofloxacin hydrochloride prices .

Drug Function and Efficacy

It achieves antibacterial effect by inhibiting the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hindering bacterial replication. It has good antibacterial effect on most Enterobacteriaceae, some Gram-positive bacteria, Legionella, mycoplasma, Chlamydia, etc., but has poor effect on anaerobic bacteria and enterococci.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levofloxacin Hydrochloride Tablets
Ingredients	Levofloxacin hydrochloride. Chemical name: (S)-(-)-9-Fluoro-2.3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-fluoro-7H-pyridine.
Indication	When this product is used simultaneously with antacids containing magnesium or aluminum, sucralfate, metal cations (such as iron), and zinc-containing multivitamin preparations, it will interfere with the absorption of this product by the gastrointestinal tract, causing the concentration of this drug in various systems to be significantly reduced. Therefore, the time of taking the above-mentioned drugs should be at least 2 hours before or after using this product. Avoid using it simultaneously with theophylline. If it is necessary to use it simultaneously, the blood concentration of theophylline should be monitored and the dosage should be adjusted accordingly. When used simultaneously with warfarin or its derivatives, the prothrombin time or other coagulation tests should be monitored. When used simultaneously with non-steroidal anti-inflammatory drugs, there is a possibility of inducing convulsions. When used simultaneously with oral hypoglycemic drugs, it may cause blood sugar disorders, including hyperglycemia and hypoglycemia. Therefore, blood sugar concentrations should be monitored during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.
Specifications	0.1g (based on C18H20FN3O4)
Manufacturer	Dingfukang Pharmaceutical Co., Ltd.

Levofloxacin Hydrochloride Eye Drops
Ingredients	Levofloxacin hydrochloride. Chemical name: S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridinyl[1,2,3-de]-[1,4]-benzoxazine-6-carboxylic acid hydrochloride monohydrate. Molecular weight: C18H20FN3O4·HCl·H20
Indication	There is still a lack of information on drug interactions with this product. However, it has been shown that some quinolones can increase the blood concentration of theophylline when administered systemically, interfere with the metabolism of caffeine, and increase the effects of oral anticoagulants such as warfarin and its derivatives. If cyclosporine is taken at the same time, patients may experience a transient increase in serum creatinine.
Specifications	0.3% (8ml: 24mg, based on C18H20FN3O4)
Manufacturer	Guangdong Hongying Technology Co., Ltd.

Levofloxacin Hydrochloride Injection
Ingredients	The main ingredients and chemical names of this product are: Levofloxacin hydrochloride, (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3,-de]-[1,4]benzoxazine-6-carboxylic acid hydrochloride monohydrate. [Molecular formula] C18H20FN3O4·HCl·H2O [Molecular weight] 415.85
Indication	1. This product cannot be used in the same infusion tube with polyvalent metal ion solutions such as magnesium and calcium. 2. Avoid using it simultaneously with theophylline. If it is necessary to use it simultaneously, the blood concentration of theophylline should be monitored and the dosage should be adjusted accordingly. 3. When used simultaneously with warfarin or its derivatives, the prothrombin time or other coagulation tests should be monitored. 4. When used simultaneously with non-steroidal anti-inflammatory drugs, it may cause convulsions. 5. When used simultaneously with oral hypoglycemic drugs, it may cause hypoglycemia. Therefore, attention should be paid to monitoring blood sugar concentration during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.
Specifications	5ml:0.1g (based on C18H20FN3O4)

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Registered Holders

Zhejiang East-Asia Pharmaceutical Co., Ltd.

China
Active
Suzhou Homesun Pharmaceutical Co., Ltd.

China
Active
Shaoxing Jingxin Pharmaceutical Co., Ltd.

China
Active

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Guide of Levofloxacin hydrochloride

Basic Attributes
Characteristics
Price Analysis
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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Levofloxacin hydrochloride

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