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Atorvastatin calcium

Atorvastatin calcium structure

CAS No:
134523-03-8
Formula:
C33H35FN2O5.¹/2Ca
Chemical Name:
Atorvastatin calcium
Synonyms:
1H-Pyrrole-1-heptanoic acid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calcium salt (2:1),(βR,δR)-;1H-Pyrrole-1-heptanoic acid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calcium salt (2:1),[R-(R*,R*)]-;CI 981;Atorvastatin calcium;YM 548;Lipitor;Atorvastatin hemicalcium;Tahor;Sortis;Atorvastatin hemicalcium salt;Storvas;Rotacor;Atocor;Atoraz;Lowlip;Lorvast;334757-04-9;1108202-55-6;1370463-14-1
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Atorvastatin calcium is an organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio. It contains an atorvastatin(1-).|Atorvastatin Calcium Anhydrous is an anhydrous calcium salt form of atorvastin, a synthetic lipid-lowering agent.|A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.

Atorvastatin calcium Basic Attributes

Molecular Weight：

1155.34000

Exact Mass：

1154.45000

UNII：

C0GEJ5QCSO

DSSTox ID：

DTXSID6044303

NCI Thesaurus Code：

C78759

HScode：

2933990090

Characteristics

PSA：

201.58000

XLogP3：

10.10380

Appearance：

White Crystalline Powder

Melting Point：

176-178ºC

Boiling Point：

722.2ºC at 760 mmHg

Flash Point：

390.6ºC

Collision Cross Section：

231.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

hazard class code：

R20/21/22

safety instructions：

S26; S36

Marks：

GHS Classification：

|Warning|H373 (48.68%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]|P260, P273, P314, P391, and P501|Aggregated GHS information provided by 79 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|Danger|H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 7 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Treatment of elevated cholesterol|Prevention of cardiovascular events in hypertensive patients and diabetes mellitus type II patients with multiple risk factors for cardiovascular disease, Treatment of concomitant angina and dyslipidaemia, Treatment of concomitant hypertension and dyslipidaemia|Prevention of cardiovascular events in hypertensive patients and diabetes mellitus type II patients with multiple risk factors for cardiovascular disease, Treatment of concomitant angina and dyslipidaemia|Treatment of hypercholesterolaemia, Treatment of mixed hyperlipidaemia|Prevention of cardiovascular events in hypertensive patients and diabetes mellitus type II patients with multiple risk factors for cardiovascular disease, Treatment of concomitant angina and dyslipidemia, Treatment of concomitant hypertension and dyslipidemia|Pure hypercholesterolaemia (heterozygous, homozygous, or otherwise primary hypercholesterolaemia), combined (mixed) hyperlipidaemia; prevention of cardiovascular events|Treatment of hyperlipidaemia, Treatment of type II diabetes mellitus

MeSH：

Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)|Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)

MeSH Entry Terms：

(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid

Atorvastatin calcium Use and Manufacturing

Uses

1. A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia
2. A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
3. Antihyperlipidemic, HMGCoA reductase inhibitor
4. DMSO and EtOH soluble
5. The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1155.3
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:22
Exact Mass:1154.4529416
Monoisotopic Mass:1154.4529416
Topological Polar Surface Area:229
Heavy Atom Count:83
Complexity:817
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific description provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Atorvastatin calcium

Atorvastatin Calcium Tablets
Specifications	40mg

Atorvastatin calcium
Ingredients	Atorvastatin Calcium Tablets
Indication	(1) The combined use of this product with oral anticoagulants can prolong the prothrombin time and increase the risk of bleeding. (2) The combined use of this product with immunosuppressants such as cyclosporine, erythromycin, gemfibrozil, niacin, etc. can increase the risk of myolysis and acute renal failure. (3) Colestipol and cholestyramine can reduce the bioavailability of this product, so this product should be taken 4 hours after taking the former.
Manufacturer	Zhejiang LEPU Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

MANKIND PHARMA LTD

United States
Active
MSN LIFE SCIENCES PRIVATE LTD

United States
Active
HEC PHARM CO LTD

United States
Active

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