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Ambroxol hydrochloride

Ambroxol hydrochloride structure

CAS No:
23828-92-4
Formula:
C13H18Br2N2O.ClH
Chemical Name:
Ambroxol hydrochloride
Synonyms:
Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,hydrochloride (1:1),trans-;Cyclohexanol,4-[(2-amino-3,5-dibromobenzyl)amino]-,hydrochloride,trans-;Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,monohydrochloride,trans-;trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride;N-(trans-4-Hydroxycyclohexyl)-2-amino-3,5-dibromobenzylamine hydrochloride;Ambroxol hydrochloride;Mucolear;Mucosolvan;Surbronc;Mucolin;Ambril;Lindoxyl;Muco-Burg;Mucovent;Stas-Hustenloser;Mucofar;Abramen;Solvolan;Mucasan;Surfactal;Fluibron;Motosol;Pect;Frenopect;Duramucal;Mucoclear;Fluixol;Bronchopront;Coughnol;Ambron;Ambrodil;Mucolite;Mucosal;Ambrolite;108728-04-7;15942-05-9
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

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Description

White Crystalline Powder

Ambroxol hydrochloride Basic Attributes

Molecular Weight：

414.56400

Exact Mass：

411.95500

EC Number：

245-899-2

HScode：

2922199090

Characteristics

PSA：

58.28000

XLogP3：

4.96100

Appearance：

white to yellowish crystalline powder

Melting Point：

233-234.5 °C (decomp)

Boiling Point：

468.6ºC at 760 mmHg

Flash Point：

237.2ºC

Water Solubility：

Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).

Storage Conditions：

2-8ºC

Toxicity：

LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn)

Safety Information

wgk germany：

hazard class code：

R22

safety instructions：

S36

RTECS Number：

GV8423000

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Ambroxol hydrochloride Use and Manufacturing

Methods of Manufacturing

341.6 g (0.931 mol) of the dried solid obtained in the second step was added to a 2000 ml flask and 1000 g of methanol was added.34.8percent concentrated hydrochloric acid 98.6g, ph is about 1, Stir for 1 hour, filter, wash and dry to obtain 374.4 g of crystalline solid in a yield of about 97percent.HPLC purity 99.7percent.

Uses

1. Expectorant
2. A metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug.
3. Skin whitening, depigmentation agent
4. Ambroxol is indicated as 鈥渟ecretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to brea

Drug Function and Efficacy

This product is a mucolytic agent that can increase the secretion of serous glands in the respiratory mucosa and reduce the secretion of mucous glands, thereby reducing sputum viscosity, promoting the secretion of pulmonary surfactant, increasing bronchial ciliary movement, and making sputum easier to cough up.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ambroxol Hydrochloride Sustained Release Capsules
Ingredients	The main ingredient of this product is ambroxol hydrochloride.
Indication	Not yet clear.
Specifications	75 mg

Ambroxol Hydrochloride Oral Solution
Ingredients	The main ingredient of this product is ambroxol hydrochloride.
Indication	If used with antitussives (cough suppressants), there is a risk of blockage of secretions due to a weakened cough reflex, so the therapeutic range of the drug must be carefully considered before combined use. If used with antibiotics (amoxicillin, cefuroxime, erythromycin or doxycycline), the penetration of the antibiotic into the lung tissue may be increased.
Specifications	100ml:0.6g
Manufacturer	MAN Yuen (FUZHOU) MEDICINE Co., Ltd.

Ambroxol Hydrochloride Tablets
Ingredients	Each tablet of this product contains 30 mg of ambroxol hydrochloride. Excipients are: lactose, microcrystalline cellulose, corn starch, sodium carboxymethyl starch, talc, and stearic acid powder.
Indication	1. Taking this product with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) at the same time may lead to increased concentration of antibiotics in lung tissue. 2. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	30 mg x 20 tablets
Manufacturer	Shandong YUXIN Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

SHILPA PHARMA LIFESCIENCES LIMITED

India
Active
Beijing Lunarsun Pharmaceutical Co., Ltd.

China
Active
Beijing Ansenbo Pharmaceutical Technology Co., Ltd.

China
Active

See More Registered Holders

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