Metoclopramide monohydrochloride monohydrate
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Metoclopramide monohydrochloride monohydrate
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CAS No:
54143-57-6
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Formula:
C14H22ClN3O2.ClH.H2O
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Chemical Name:
Metoclopramide monohydrochloride monohydrate
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Synonyms:
Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-,hydrochloride,hydrate (1:1:1);Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-,monohydrochloride,monohydrate;Metoclopramide monohydrochloride monohydrate
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CAS No:
Description
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve
Metoclopramide hydrochloride is a hydrate that is the monohydrate form of metoclopramide monohydrochloride. It has a role as a gastrointestinal drug, a dopaminergic antagonist and an antiemetic. It is a hydrate and a hydrochloride. It contains a metoclopramide(1+).|Metoclopramide Hydrochloride is the hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.|A dopamine D2 antagonist that is used as an antiemetic.
Metoclopramide monohydrochloride monohydrate Basic Attributes
336.25700
335.11700
W1792A2RVD
C649
2924296000
Characteristics
67.59000
3.77650
182.5-184°
418.7ºC at 760mmHg
207ºC
It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane.
Safety Information
NONH for all modes of transport
3
P301 + P312 + P330-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. (See all compounds classified as Dopamine D2 Receptor Antagonists.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
Metoclopramide monohydrochloride monohydrate Use and Manufacturing
Strong central antiemetic effect is only effective for vomiting caused by drugs, uremia and radiotherapy
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:354.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:353.1272971
Monoisotopic Mass:353.1272971
Topological Polar Surface Area:68.6
Heavy Atom Count:22
Complexity:300
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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Metoclopramide monohydrochloride monohydrate
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