Trisodium phosphate

163.94100

163.92300

231-509-8

SX01TZO3QZ

1178

3262|3082

DTXSID2035223

Colorless crystals

A - Alimentary tract and metabolism|B - Blood and blood forming organs

2835311000

96.06000

0.38600

DryPowder; DryPowder, PelletsLargeCrystals, WetSolid; Liquid; PelletsLargeCrystals

2.536 g/cm³ @ Temp: 17.5 °C

75 °C (decomp)

158ºC at 760 mmHg

Solubility in water, g/l at 20°C: 121 (good)

Keep containers tightly closed in a well ventilated area away from food products. Keep away from heat and water. If allowed to p

LD50 skin in rabbit: > 300mg/kg

Between 11,5 and 12,5 (1 % solution)

Crystallizes with 8 and 12 mols of H2O.|Colorless, trigonal crystals; MP: approx 75 °C; density: 1.62 g/cu cm; solubility: 14.4 g/100 g water at 25 °C; qualitative solubility: insoluble in ethanol /Trisodium phosphate dodecahydrate/|Trisodium phosphate tends to pick up moisture from air and form a hard cake.

When wet, mild steel or brass may be corroded by trisodium phosphate.

III

8

UN 9148/3262

1

R34

S26-S36/37/39-S45

TC9490000

C

Separated from strong acids. Dry. Well closed.

Rapidly absorbs water if exposed to moist atmosphere /Dried sodium phosphate/

P261-P305 + P351 + P338

H315-H319-H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Sodium phosphate (mono-, di-, & tribasic) used as a multiple purpose food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Sodium phosphate (mono-, di-, & tribasic)/|Sodium phosphate (mono-, di-, & tribasic) used as a sequesterant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Sodium phosphate (mono-, di-, & tribasic)/|Sodium phosphate (mono-, di-, & tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Sodium phosphate (mono-, di-, & tribasic)/|Sodium phosphate (mono-, di-, & tribasic) used as a general purpose food additive animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Sodium phosphate (mono-, di-, & tribasic/|For more FDA Requirements (Complete) data for TRISODIUM PHOSPHATE (6 total), please visit the HSDB record page.

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.|Reactive - 1st degree

|Warning|H315 (90.61%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 1281 companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P321, P332+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|Danger|H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501

Personnel Protection: Wear appropriate chemical protective gloves, boots and goggles.

NONFLAMMABLE. /SODIUM PHOSPHATE, TRIBASIC DODECAHYDRATE/

If material is on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)

Behavior in fire: May melt with loss of steam. /Sodium Phosphates/

/SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental Considerations: Water Spill Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required.|If material is not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.|For more Preventive Measures (Complete) data for TRISODIUM PHOSPHATE (7 total), please visit the HSDB record page.

Acute exposures to trisodium phosphate may cause irritation of the respiratory system with subsequent coughing and pain.

Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from strong acids. Dry. Well closed.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

In rabbits fed an arteriosclerosis-inducing diet, simultaneous feeding of trisodium phosphate (50 mg/kg diet) prevented for the 1st month the rise in plasma total lipids and total cholesterol seen in the unmedicated controls. For the next month, these parameters increased to some extent, but less than in the controls. The mechanism of action is thought to involve the metabolism of inorganic phosphate.

LD50 Rat oral 4.8 mg/kg|LD50 Rat oral >2000 mg/kg|LD50 Rat inhalation /greater than or equal to/ 2.16 mg/L/1 hr|LD50 Rabbit dermal /greater than or equal to/ 2 mg/kg bw

Two-year toxicology and carcinogenesis studies of chlorinated trisodium phosphate, an inclusion complex of trisodium phosphate and sodium hypochlorite used in various cleaning compounds, were conducted by administering 0,500, or 1,000 mg/kg (dose volume: 10 mL/kg) of the chemical in water by gavage, 5 days per week for 103 weeks, to groups of 50 male and 50 female B6C3F1 mice. Groups of mice receiving 250 mg/kg were included in these studies but were removed after 6 months because of a lack of toxicity in the 500 and 1,000 mg/kg groups. Two-year studies were begun in male and female F34M rats at doses of 0, 500, 1,000, or 2,000 mg/kg of chlorinated trisodium phosphate in water by gavage (10 mL/kg). The 2,000 mg/kg groups were killed at 15 weeks because of poor survival, and the other groups were killed at 35 weeks because of toxicity in the 1,000 mg/kg group. ... Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenicity for either male or female B6C3F1 mice given chlorinated trisodium phosphate by gavage in water for 103 weeks at doses of 500 or 1,000 mg. Survival of dosed female mice was 78% and 72% after 80 weeks and 32% and 42% at the termination of the study. The studies in male and female F344/N rats were considered to be inadequate studies of carcinogenicity because the experiments were terminated at 35 weeks due to poor survival. /Chlorinated trisodium phosphate/|Chlorinated trisodium phosphate was weakly mutagenic in strain TA1535 of Salmonella typhimurium in the presence of Aroclor 1254 induced male Sprague-Dawley rat or male Syrian hamster liver S9. This compound was not mutagenic in strains TA97, TA98, or TA100. /Chlorinated trisodium phosphate/

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,163 workers (278 of these were female) were potentially exposed to trisodium phosphate in the US(1). Occupational exposure to trisodium phosphate may occur through inhalation and dermal contact with this compound at workplaces where trisodium phosphate is produced or used.

Sodium orthophosphate is poorly absorbed & relatively nontoxic /SRP: systemically/|/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic acids and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. Activated charcoal is not effective. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Inorganic acids and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's(LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Inorganic acids and related compounds/

/SIGNS AND SYMPTOMS/ Acute exposures to trisodium phosphate may cause irritation of the respiratory system with subsequent coughing and pain. In severe exposures pulmonary edema may develop.|/SIGNS AND SYMPTOMS/ Splash of aq soln in human eyes ... /causes/ slight transient injury. ... Known ... to have caused moderate permanent corneal opacification & vascularization similar to ... sodium hydroxide. In one of latter cases soln was hot, & this undoubtedly incr its injurious effect.|/SIGNS AND SYMPTOMS/ Aq soln are highly alkaline and may produce caustic burn.|/SIGNS AND SYMPTOMS/ The estimated fatal dose of sodium phosphates is 50 g. The corrosive effect is strong irritation & erythema, blistering. /Alkalies & phosphates; from table/|For more Human Toxicity Excerpts (Complete) data for TRISODIUM PHOSPHATE (9 total), please visit the HSDB record page.

dibasic sodium phosphate, anhydrous

Serious local effects by all routes of exposure.

Cough. Sore throat. Burning sensation. Shortness of breath.

Skin burns. Pain.

Redness. Pain. Severe deep burns.

46% AS AN INDUSTRIAL & INSTITUTIONAL DETERGENT BUILDER & IN WATER TREATMENT; 27% AS A HOUSEHOLD DETERGENT BUILDER & IN WATER TREATMENT; 19% IN ELASTOMERS & FOR EXPORT; 7% IN HOUSEHOLD SCOURING CLEANSERS; 1% AS EMULSIFIER IN PROCESSED CHEESE (1973).

Trisodium phosphate, 1-4% in Crest Fluoride gel and Crest Fluoride toothpaste.|Anhydrous, technical grades: anhydrous and crystalline, granular and powder food grades.|Grade: Commercial, high purity, CP /chemically pure - a grade designation signifying a minimum of impurities, but not 100% purity/, FCC (anhydrous), anhydrous salt

Agriculture, forestry, fishing and hunting|Phosphoric acid, sodium salt (1:3): ACTIVE|Phosphoric acid, C14-18 and C16-18-unsatd. alkyl esters, sodium salts: ACTIVE|... AS MICROBIOLOGICAL /INHIBITOR/ ... & AS SYNERGIST FOR OTHER PRESERVATIVES. ... IMMERSING FRUITS IN A SOLUTION OF TSP ... & DRYING THEM SO THAT A FILM OF THE PHOSPHATE REMAINS, PARTICULARLY IN SURFACE CUTS, SCRATCHES, OR ABRASIONS, THE DECAY OF FRUITS WAS DELAYED FOR A SIGNIFICANT PERIOD OF TIME.|... THE PHOSPHATES PREFERRED FOR TENDERIZATION OF BEEF /INCLUDED/ ... TSP.|... MIXING APPROX 1% TRISODIUM PHOSPHATE WITH STARCH RENDERED IT FLUIDIZABLE FOR TREATMENT IN A FLUID BED, WHERE IT COULD BE HEATED TO DEXTRINIZE THE STARCH.|CONTROLLING THE PH OF PROTEIN SOLN HAS LONG BEEN RECOGNIZED AS IMPORTANT IN INCR THEIR WATER ABSORPTION. ... THE WATER ABSORPTION OF SOYBEAN PROTEIN COULD BE INCR IF THE PH WAS MAINTAINED WITHIN THE ALKALINE RANGE OF 7.0-9.0. A NUMBER OF ALKALINE SALTS COULD BE USED FOR THIS PURPOSE, AMONG WHICH WAS TSP.|For more General Manufacturing Information (Complete) data for TRISODIUM PHOSPHATE (8 total), please visit the HSDB record page.

Method: NIOSH 7300, Issue 3; Procedure: inductively coupled argon plasma, atomic emission spectroscopy (nitric/perchloric acid ashing); Analyte: phosphorus; Matrix: air; Detection Limit: 3.7 ng/mL. /Phosphorus/|Method: NIOSH 7301, Issue 1; Procedure: inductively coupled argon plasma, atomic emission spectroscopy (aqua regia ashing); Analyte: phosphorus; Matrix: air; Detection Limit: 3.7 ng/mL. /Phosphorus/|Method: NIOSH 7303, Issue 2; Procedure: inductively coupled argon plasma, atomic emission spectroscopy (hot block/HCl/HNo3 digestiion; Analyte: phosphorus; Matrix: air; Detection Limit: 0.3 ug/mL. /Phosphorus/|Method: NIOSH 7905, Issue 2; Procedure: gas chromatography, flame photometric detector (phosphorus mode); Analyte: phosphorus; Matrix: air; Detection Limit: 0.005 ug/sample. /Phosphorus/|Method: NIOSH 9102, Issue 1; Procedure: inductively coupled argon plasma, atomic emission spectroscopy; Analyte: phosphorus; Matrix: air; Detection Limit: 0.043 ug/wipe. /Phosphorus/

EPA Safer Chemical Functional Use Classes -> Oxidants and Oxidant Stabilizers|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Food additives|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Fire Hazards -> Reactive - 1st degree|Cosmetics -> Buffering; Chelating

Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER;