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Troxipide

Troxipide structure

CAS No:
30751-05-4
Formula:
C15H22N2O4
Chemical Name:
Troxipide
Synonyms:
Benzamide,3,4,5-trimethoxy-N-3-piperidinyl-;Benzamide,3,4,5-trimethoxy-N-3-piperidyl-;3,4,5-Trimethoxy-N-3-piperidinylbenzamide;3-(3,4,5-Trimethoxybenzamido)piperidine;KU 54;Troxipide;Aplace;(N-Piperidin-3-yl)-3,4,5-trimethoxybenzamide;99777-81-8
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

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Description

Troxipide is a novel gastro protective agent with antiulcer, anti-inflammatory and mucus secreting properties.

Troxipide is a member of benzamides.

Troxipide Basic Attributes

Molecular Weight：

294.34600

Exact Mass：

294.35

DSSTox ID：

DTXSID2023725

ATC Code：

A - Alimentary tract and metabolism

HScode：

2933399090

Characteristics

PSA：

68.82000

XLogP3：

1.91390

Appearance：

white powder

Density：

1.18g/cm3

Melting Point：

179-185 °C

Boiling Point：

407.5ºC at 760 mmHg

Flash Point：

200.3ºC

Refractive Index：

1.546

Safety Information

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

3-(3,4,5-trimethoxybenzamido)piperidine

Troxipide Use and Manufacturing

Troxipide is a drug used in the treatment of gastroesophageal reflux disease. Troxipide is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. Troxipide is currently marketed in Japan (Aplace), China (Shuqi), South Korea (Defensa), and India (Troxip). It is used for the management of gastric ulcers, and amelioration of gastric mucosal lesions in acute gastritis and acute exacerbation of chronic gastritis.

Computed Properties

Molecular Weight:294.35
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:294.15795719
Monoisotopic Mass:294.15795719
Topological Polar Surface Area:68.8
Heavy Atom Count:21
Complexity:326
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is a new type of defense factor-enhanced gastritis and gastric ulcer therapeutic agent. It has an inhibitory effect on various experimental ulcers, a therapeutic and preventive effect on experimental gastritis, and a preventive effect on acute gastric mucosal lesions. It can enhance the blood flow of the gastric mucosa and promote tissue repair. Unlike H2-receptor antagonists, it has no effect on gastric acid secretion, but enhances the defense factors of the gastric mucosa and promotes the repair of gastric ulcer sites.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Troxipide Tablets
Ingredients	The main ingredient of this product: Troxipitide.
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Hubei Qianjiang Pharmaceutical Co., Ltd.

Troxipad Capsules
Ingredients	Main ingredient: Troxipad, chemical name: (±) 3,4,5-trimethoxy-N-3-azacyclohexylcarboxamide
Indication	Concomitant use with beta-blockers or antiarrhythmic drugs may increase the cardiac depressant effect.
Specifications	0.1g
Manufacturer	PKU HealthCare Corp., Ltd.

Troxipad Capsules
Ingredients	Main ingredient: Troxipad, chemical name: (±) 3,4,5-trimethoxy-N-3-azacyclohexylcarboxamide
Indication	Concomitant use with beta-blockers or antiarrhythmic drugs may increase the cardiac depressant effect.
Specifications	0.1g
Manufacturer	PKU HealthCare Corp., Ltd.

See More Related Drugs

Registered Holders

PKU HealthCare Corp., Ltd.

China
Active
Hanrui Pharmaceutical (Jingmen) Co., Ltd.

China
Inactive

Recommended Suppliers of Troxipide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
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Troxipide

CAS No.: 30751-05-4

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