 Home > Encyclopedia > Potassium oxonate

Potassium oxonate

Potassium oxonate structure

CAS No:
2207-75-2
Formula:
C4H3N3O4.K
Chemical Name:
Potassium oxonate
Synonyms:
1,3,5-Triazine-2-carboxylic acid,1,4,5,6-tetrahydro-4,6-dioxo-,potassium salt (1:1);Allantoxanic acid,monopotassium salt;1,3,5-Triazine-2-carboxylic acid,1,4,5,6-tetrahydro-4,6-dioxo-,monopotassium salt;Allantoxanic acid,potassium salt;Potassium azaorotate;Potassium 2,6-dihydroxytriazinecarboxylate;Potassium oxonate;Potassium otastat;Oteracil potassium;20636-38-8;1001850-52-7
Categories:
Organic Chemistry > Organometalate

Description

Oxonic acid potassium salt is an inhibitor of uricase, oxonic inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-mo

Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.|Oteracil Potassium is the potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy.

Potassium oxonate Basic Attributes

Molecular Weight：

195.17500

Exact Mass：

194.96800

EC Number：

218-627-5

UNII：

4R7FFA00RX

DSSTox ID：

DTXSID5046568

NCI Thesaurus Code：

C2415

HScode：

2933699090

Characteristics

PSA：

118.74000

Melting Point：

>300 °C

Water Solubility：

Soluble in hot water.

Storage Conditions：

Store in a cool, dry place. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, we

Safety Information

wgk germany：

safety instructions：

S24/25

RTECS Number：

RR4580000

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

potassium oxonate

Potassium oxonate Use and Manufacturing

Methods of Manufacturing

3.2Kg potassium hydroxide dissolved in 11.4L water, dissolved after adding 20L reactor, Cooling to 0 ~ 5 , Add 46g potassium iodide, add 0.9kg allantoin in batches, Stirring dissolved, Temperature control 0 ~ 5 drop 1.8kg bromine to be 9h (according to the different bromine drop time, respectively, as the first 1-8 groups)After completion of the dropwise addition, stirring at 0 to 5 ° C for 1 hour and raising the temperature to 20 to 25 ° C for 20 h, HPLC to detect allantoin less than 0.6percent, cooling to 0 ~ 5 , dropping acetic acid to adjust the pH to 5, filtration, 3L0 ~ 5 water washing, 1L room temperature ethanol wash, Dry at room temperature with white oxonate potassium crystalline solid.

Uses

1. Antitumor effect potentiator and antitumor agent
2. Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

Computed Properties

Molecular Weight:195.17
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:194.96823704
Monoisotopic Mass:194.96823704
Topological Polar Surface Area:111
Heavy Atom Count:12
Complexity:274
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has a selective antagonistic effect on orotate phosphoribosyltransferase distributed in the digestive tract, thereby selectively inhibiting the conversion of 5-FU to 5-FUMP and reducing digestive tract toxicity.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

S-1 tablets
Ingredients	It mainly contains 20 mg of tegafur, 5.8 mg of gimeracil, and 19.6 mg of oteracil potassium.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains: Tegafur 20mg, Gimeracil 5.8mg, Oteracil Potassium 19.6mg
Manufacturer	Qilu Pharmaceutical Co., Ltd.

S-1 Capsules
Ingredients	This product is a compound preparation, the main ingredients of which are tegafur, gimeracil and oteracil potassium.
Indication	1. Do not use the following drugs in combination with fluorouracil anti-tumor drugs; fluorouracil (5-Fu, etc.); tegafur-uracil combination preparations (UFT, etc.); tegafur; doxifluridine; capecitabine; carmofur. Early combined use can lead to serious blood system disorders and digestive tract dysfunctions such as diarrhea and stomatitis. After discontinuing this product, wait at least 7 days before using other drugs. After other drugs are discontinued, this product should also be given again after an appropriate interval. The gimeracil in this product can inhibit the catabolism of 5-FU in the combined drugs, significantly increasing the blood concentration of 5-FU. Leucovorin, tegafur and uracil combined chemotherapy; leucovorin calcium and fluorouracil combined chemotherapy. Fluoropyrimidine antifungal drugs; flucytosine. 2. Be cautious when using the following drugs in combination with phenytoin sodium. Phenytoin may occur
Specifications	25mg

S-1 Capsules
Ingredients	This product is a compound preparation. Each capsule contains: 20 mg of tegafur, 5.8 mg of gimeracil, and 19.6 mg of oteracil potassium.
Indication	(1) Contraindications for combined use of drugs (This product should not be used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Fluorouracil antineoplastic drugs Fluorouracil (5-Fu, etc.) Tegafur-uracil combination preparations (UFT, etc.) Tegafur (Futraful) Doxifluridine (Furtulon) Capecitabine (Xeloda) Camofur (Mifurol) Combined use of drugs can lead to serious blood system disorders and digestive tract dysfunction such as diarrhea and stomatitis in the early stage. After discontinuing this product, it is necessary to wait at least 7 days before using other drugs. After discontinuing other drugs, it is also necessary to give this product again after an appropriate interval. The gimeracil in this product can inhibit the catabolism of 5-FU in the combined drug, causing a significant increase in the blood 5-FU concentration (refer to the pharmacokinetic item). Folinic acid Tegafur Uracil combined chemotherapy (folinic acid UFT, etc.) Calcium folinate Fluorouracil combined chemotherapy (calcium folinate 5-FU) Fluoropyrimidine antifungal drugs Flucytosine (2) Precautions for combined use (Caution should be taken when this product is used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Phenytoin sodium Phenytoin sodium poisoning (nausea, vomiting, nystagmus, movement disorders, etc.) can occur. Closely observe the patient's condition. If abnormalities are found, stop using this product immediately and take appropriate measures. Tegafur can inhibit the metabolism of phenytoin sodium and increase its blood concentration. Dicoumarin potassium This product can enhance the effect of dicoumarin and lead to abnormal coagulation function. The mechanism is unknown Other anti-tumor drugs Radiation exposure, etc. can enhance the side effects of the blood system and digestive system. Pay attention to the patient's condition. If abnormalities are found, appropriate measures such as reducing the dose or stopping the drug should be taken. Side effects enhance each other.
Specifications	Each tablet contains: Tegafur 25mg, Gimeracil 7.25mg, Oteracil Potassium 24.5mg
Manufacturer	Qilu Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Sumitomo Chemical Co.,Ltd

Japan
Active
KYONGBO PHARMACEUTICAL CO., LTD

South Korea
Active
Gansu Zhizi Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Potassium oxonate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Potassium oxonate

CAS No.: 2207-75-2

Content: 99.00%

Inquiry
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Potassium oxonate >=98.0% API Antibiotics made in china

CAS No.: 2207-75-2

Inquiry
Shandong Zhongke Taidou Chemical CO LTD Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of Pitavastatin Calcium

Oteracil Potassium

CAS No.: 2207-75-2

Grade: Pharmaceutical Grade

Inquiry
SAS Applied Research & Lab Materials Pvt Contact Supplier

IN
6 YRS

Business licensed Verified Supplier

Trader Supplier of FINECHEMCIALS,Speciality Chemicals,New Chemical Entity,Bulk Intermediates,INTERMIDATES,IMPURITIES,API

4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid

CAS No.: 2207-75-2

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale Potassium Oxonate 99% high quality see COA KANBEI

CAS No.: 2207-75-2

Grade: Industrial Grade

Content: 99%

Inquiry