SM 9018

Perospirone Hydrochloride

(1) It is strictly forbidden to use it in combination with adrenaline; (2) When used in combination with central nervous system depressants (barbituric acid derivatives), due to the possibility of mutual enhancement of central nervous system depressant effects, the drug should be administered with caution, such as reducing the dosage; (3) When used in combination with dopaminergic drugs (levodopa preparations, bromocriptine mesylate), due to the possibility of mutual weakening effects, the drug should be administered with caution, such as reducing the dosage; (4) When used in combination with antihypertensive drugs, due to the possibility of mutual enhancement of antihypertensive effects, the drug should be administered with caution, such as reducing the dosage; (5) When used in combination with domperidone and metoclopramide, it is easy to cause endocrine dysfunction or extrapyramidal symptoms; (6) When used in combination with H2 receptor antagonists (cimetidine), it may enhance the inhibitory effect of gastric acid secretion. It is necessary to observe carefully and administer the drug with caution; (7) When used in combination with P450 3A4 enzyme selective inhibitors (macrolide antibiotics), the blood concentration of this product may increase, which may lead to an increase in the incidence of adverse reactions. It is necessary to observe carefully and administer the drug with caution. (8) When used in combination with drugs metabolized by P450 3A4 enzyme (cisapride, triazolam), the incidence of adverse reactions of both drugs increases. It is necessary to observe carefully and administer the drug with caution.