Famotidine
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Famotidine
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CAS No:
76824-35-6
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Formula:
C8H15N7O2S3
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Chemical Name:
Famotidine
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Synonyms:
FAMOTIDINE;[amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]-methyl]thio]propylidene]s;3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-n-(aminosulfonyl)p;3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)-n(sup2)-sulfamoylp;Famotidine USP&BP;FAMOTIDINE, IMP. A (EP) AS HYDROCHLORIDE: 3-[[[2-[DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]PROPANIMIDAMIDE HYDROCHLORIDE MM(CRM STANDARD);FAMOTIDINE, IMPURITY C BP STANDARD;FAMOTIDINE, IMP. B (EP) AS DIMALONATE: 3,5-[2-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]ETHYL]-4H-1,2,4,6-THIATRIAZINE 1,1-DIOXIDE DIMALONATE MM(CRM STANDARD)
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CAS No:
Description
Famotidine is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.Target: Histamine H2 ReceptorFamotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). Famotidine Group(2 mg/kg/day) were significantly lower than the equivalent parameters for the Control Group on both the th
Famotidine (Chemical formula: C8H15N7O2S3; Brand Name: PEPCID) belongs to a histamine H2-receptor antagonist. It appears as a white to pale yellow crystalline compound. Inside the body, its primary activity is inhibiting the gastric secretion process, further reducing the acid concentration and volume of gastric secretion in the stomach. Based on this property, it is used for the treatment and prevention of ulcers occurring in the stomach and intestines. It can also treat diseases such as Zollinger-Ellison syndrome in which the stomach accumulates excess amount of acids. Moreover, it is also applied during the treatment of gastroesophageal reflux disease (GERD) and pathological hypersecretory conditions.
White Powder
Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Characteristics
238
-0.64
Solid
1.5111 (rough estimate)
163-164°C
562.7±60.0 °C(Predicted)
354.4±34.3 °C
1.7400 (estimate)
1.1 mg/mL
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
<0.0000001 kPa ( 25 °C)
LD50 i.v. in mice: 244.4 mg/kg (Yasufumi)
pKa 6.76(H2O t=23.0) (Uncertain)
2-8°C
Safety Information
NONH for all modes of transport
2
T
22-24/25-53-45-36/37/39
UA2300000
T
Store at -20°C
20/21/22-45-61
Contact dermatitis in a nurse from famotidine, an H2-receptor agonist, was described. In industry, three cases were reported due to intermediates of the synthesis of 2-diamino-ethylene-amino-thiazolyl-methylenethio urea-dichloride, and 4-chloromethyl-2-guanidinothiaz ole-nitrochloride.
Famotidine Use and Manufacturing
Use as an H2-antagonist.An anti-ulcer agent
Histamine H2-receptor antagonist. Antiulcerative.
antiinflammatory
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Contact dermatitis from famotidine, a H2 -receptor agonist, was described in a nurse. In industry, three cases were reported due to intermediates of synthesis, 2- diamino-ethylene-amino-thiazolyl-methylenethiourea-dichloride and 4-chloromethyl-2-guanidinothiazolenitrochloride.
Drug Function and Efficacy
This product is a H2 receptor antagonist of the guanyl thiazole class, which has the characteristics of high affinity for H2 receptors, and has a significant inhibitory effect on gastric acid secretion, and has an inhibitory effect on basal secretion and the increase of gastric acid and pepsin caused by various stimuli. This product does not change the gastric emptying rate, does not interfere with pancreatic function, and has no adverse effects on the cardiovascular system and kidney function. This product is different from cimetidine, but it is similar to ranitidine, that is, long-term high-dose treatment does not cause androgen antagonism side effects such as male breast development, impotence, lack of libido, and female breast pain and galactorrhea, etc. It has no teratogenic, carcinogenic, drug enzyme inhibitory and androgen inhibitory effects.
Registered Holders
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MSN LIFE SCIENCES PRIVATE LTD
Active
United States
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AZICO BIOPHORE INDIA PVT LTD
Active
United States
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ALEMBIC PHARMACEUTICALS LTD
Active
United States
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