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Clindamycin phosphate

Clindamycin phosphate structure

CAS No:
24729-96-2
Formula:
C18H34ClN2O8PS
Chemical Name:
Clindamycin phosphate
Synonyms:
L-threo-α-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,2-(dihydrogen phosphate);L-threo-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,2-(dihydrogen phosphate),trans- α-;L-threo-α-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,2-(dihydrogen phosphate),(2S-trans)-;Clindamycin 2-phosphate;Methyl 7-chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate);7(S)-Chloro-7-deoxylincomycin 2-phosphate;Cleocin phosphate;U 28508;Clindamycin phosphate;Dalacin P;Dalacin T;Cleocin T;Clindets;NSC 618653;Clindesse;Clindagel;Clindac;Clinadac;27999-45-7;1044582-65-1
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Clindamycin phosphate is an antibiotic, which blocks the ribosomes of microorganisms. It is usually used to treat infections with anaerobic bacteria, can also be used to treat protozoal diseases, such as malaria.

Clindamycin phosphate Basic Attributes

Molecular Weight：

504.97

Exact Mass：

504.96

EC Number：

246-433-0

DSSTox ID：

DTXSID1048677

HScode：

29419000

Characteristics

PSA：

174

XLogP3：

0.83530

Appearance：

White solid

Density：

1.4±0.1 g/cm3

Melting Point：

114 °C

Refractive Index：

1.577

Water Solubility：

Freely soluble in water;DMSO: soluble 224mg/mL at 25°C

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

36-26

RTECS Number：

GF2625000

Marks：

Xn,Xi

Stability/Shelf Life：

Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (99.53%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 211 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Treatment of acne vulgaris

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Cleocin phosphate

Clindamycin phosphate Use and Manufacturing

Uses

Clindamycin 2-phosphate is a salt of clindamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:505.0
XLogP3:-1.2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:504.1462019
Monoisotopic Mass:504.1462019
Topological Polar Surface Area:174
Heavy Atom Count:31
Complexity:658
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Clindamycin phosphate is a chemically synthesized clindamycin derivative that has no antibacterial activity in vitro. After entering the body, it is rapidly hydrolyzed into clindamycin to exert antibacterial activity. It is active against aerobic Gram-positive cocci (such as Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus, and Pneumococcus), anaerobic Gram-negative rods (such as Bacteroides and Fusobacterium), anaerobic Gram-positive non-spore-forming rods (such as Propionibacterium, Eubacterium, and Actinomyces), and anaerobic and microaerophilic Gram-positive rods (such as Peptococcus, microaerophilic Streptococcus, and Peptostreptococcus).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Clindamycin Phosphate for Injection
Ingredients	The main ingredient of this product is clindamycin phosphate
Indication	1. This product can enhance the effect of neuromuscular blockers, and the two should be avoided as much as possible. 2. This product can enhance the neuromuscular blockade of inhaled anesthetics, leading to skeletal muscle weakness and respiratory depression or paralysis (apnea). Caution should be taken when using it together during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective. 3. Clindamycin phosphate has a neuromuscular blocking effect. When used in combination with antimyasthenic drugs, the latter's effect on skeletal muscle will be weakened. In order to control the symptoms of myasthenia, the dose of antimyasthenic drugs should be adjusted during the combined treatment. 4. When used with antiperistaltic antidiarrheal drugs, clindamycin phosphate may cause pseudomembranous colitis with severe watery diarrhea during the treatment course or even several weeks after the treatment course. Because it can delay the elimination of colonic endotoxins, thereby causing prolonged and aggravated diarrhea, it should not be used with antiperistaltic antidiarrheal drugs. 5 Chloramphenicol or erythromycin can compete with clindamycin phosphate at the target site, or inhibit the latter's binding to the bacterial ribosome 50s subunit, so clindamycin phosphate should not be used in combination with chloramphenicol or erythromycin. 6 When used in combination with opioid analgesics, the respiratory depressant effect of clindamycin phosphate and the central respiratory depressant effect of opioids may lead to prolonged respiratory depression or paralysis (apnea) due to cumulative phenomena, so patients must be closely observed or monitored. 7 Clindamycin phosphate is contraindicated when used with neomycin and kanamycin for intravenous drip in the same bottle. 8 It is forbidden to be used with ampicillin, phenytoin sodium, barbiturate hydrochloride, aminophylline, calcium gluconate and magnesium sulfate.
Specifications	According to clindamycin: 0.6g
Manufacturer	HE BEI YI PIN Pharmaceutical Co., Ltd.

Clindamycin Phosphate Injection
Ingredients	Clindamycin phosphate.
Indication	This product is antagonistic to erythromycin and should not be used together.
Specifications	2ml:0.3g (calculated according to C18H33CIN2O5S)
Manufacturer	Anhui Golden Sun Biochemical Pharmaceutical Co., Ltd.

Clindamycin phosphate suppository
Ingredients	Molecular weight: C18H34ClN2O8PS
Indication	1. Clindamycin phosphate can enhance the effects of neuromuscular blockers, so the two should not be used together. 2. Clindamycin phosphate and erythromycin have antagonistic effects, so they should not be used together.
Specifications	100mg (as clindamycin)
Manufacturer	Jiangxi Jiuhua Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

XINYU PHARMACEUTICAL CO LTD

United States
Active
ZYDUS LIFESCIENCES LTD

United States
Active
UNION QUIMICO FARMACEUTICA SA (UQUIFA SA)

United States
Active

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