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Butenafine hydrochloride

Butenafine hydrochloride structure

CAS No:
101827-46-7
Formula:
C23H27N.ClH
Chemical Name:
Butenafine hydrochloride
Synonyms:
1-Naphthalenemethanamine,N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-,hydrochloride (1:1);1-Naphthalenemethanamine,N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-,hydrochloride;KP 363;Butenafine hydrochloride;Mentax;Scorba
Categories:
Organic Chemistry > Amides

Description

Butenafine hydrochloride is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.IC50 Value: Target: Antifungal; squalene epoxidaseButenafine Hydrochloride, a benzylamine derivative, is an antifungal which is used to control dermal fungal infections such as athletes foot and ring worm. Butenafine Hydrochloride is squalene epoxidase inhibitor, inhibits the synthesis of ergosterol needed in fungal cell membranes. The drug has exc

Butenafine hydrochloride is the hydrochloride salt of butenafine. An inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, it is used for treatment of dermatological fungal infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and an antifungal drug. It is a hydrochloride and an ammonium salt. It contains a butenafine.|Butenafine Hydrochloride is the hydrochloride salt form of butenafine, a synthetic benzylamine derivative with fungicidal properties. Butenafine hydrochloride interferes with the biosynthesis of ergosterol, an important component of fungal cell membranes, by inhibiting the epoxidation of squalene. This alters fungal membrane permeability and causes growth inhibition. Butenafine hydrochloride is active against a number of dermatophytes, including Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Sporothrix schenckii, and yeasts, including Candida albicans and C. parapsilosis.

Butenafine hydrochloride Basic Attributes

Molecular Weight：

353.92800

Exact Mass：

353.19100

UNII：

R8XA2029ZI

DSSTox ID：

DTXSID2048589

NCI Thesaurus Code：

C47426

HScode：

2921499090

Characteristics

PSA：

3.24000

XLogP3：

6.57130

Appearance：

White crystalline powder

Density：

1.032g/cm3

Melting Point：

200-202 °C

Boiling Point：

426.1ºC at 760 mmHg

Flash Point：

187.7ºC

Refractive Index：

1.598

Vapor Pressure：

1.82E-07mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

R21

RTECS Number：

QJ8585000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H312

GHS Classification：

|Warning|H312 (97.56%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P280, P302+P352, P312, P322, P363, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

butenafine

Butenafine hydrochloride Use and Manufacturing

Uses

An antifungal, used to control dermal fungal infections such as athletes foot and ring worm.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:353.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:353.1910276
Monoisotopic Mass:353.1910276
Topological Polar Surface Area:3.2
Heavy Atom Count:25
Complexity:374
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antifungal

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Butenafine Hydrochloride Cream
Specifications	10g:0.1g

Butenafine Hydrochloride

Butenafine hydrochloride spray
Ingredients	Each bottle of this product contains 0.1g of butenafine hydrochloride. Excipients are: ethanol, propylene glycol, polysorbate 80.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	10 ml: 0.1 g
Manufacturer	Lunan BETTER Pharmaceutical Co., Ltd.

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Registered Holders

株式会社パーマケム・アジア

Japan
Active
Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active
Yunnan Longrun Pharmaceutical Co., Ltd.

China
Active

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