Glycol monobutyl ether acetate

160.211

160.21

203-933-3

WK5367RE39

0839

1993

DTXSID1026904

Colorless liquid

2915390090

35.53000

1.51

Ethylene glycol monobutyl ether acetate is a colorless liquid with a weak fruity odor. Floats and mixes slowly with water. (USCG, 1999)

0.9422 g/cm³ @ Temp: 20 °C

-64 °C

192.3 °C

76.1±0.0 °C

1.414

1.5%

Separated from strong oxidants, and strong bases. Cool. Keep in the dark.

0.3 mmHg

Relative vapour density (air = 1): 5.5

Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

Explosive limits , vol% in air: 0.9 (at 93°C) - 8.5 (at 135°C)

Fruity

5.46e-06 atm-m3/mole|Henry's Law constant = 5.46X10-6 atm-cu m/mol

Percent in saturated air: approx 0.044-0.06 at 25 °C|Conversion factors: 1 ppm is equiv to 6.54 mg/cu m; 1 mg/l is equiv to 157 ppm at 25 °C, 760 mm Hg|Hydroxyl radical reaction rate constant = 2.1X10-11 cu cm/molec-sec at 25 °C (est)

Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). It is an ether-ester derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones.

2-Butoxyethyl acetate|D*: Other compounds that may form peroxides|1 samples, > 1 yr, 3 ppm|Management of time-sensitive chemicals (JCHAS)

645 °F (USCG, 1999)|645 °F (340 °C)|340 °C

Lower = 0.88% at 200 °F (93 °C), upper 8.54% at 275 °F (135 °C)|Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

1993

1

R20/21

S24

KJ8925000

Xn:Harmful;

Separated from strong oxidants and strong bases. Cool. Keep in the dark.

Combustible. Incompatible with strong oxidizing agents.

P280

H312 + H332

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Oxidizers.|... Reacts with strong oxidants and strong bases, causing fire and explosion hazard.

Ethylene glycol monobutyl ether acetate is an indirect food additive for use only as a component of adhesives.

European Commission; European Union Risk Assessment Report for 2-Butoxyethanol Acetate (EBBEA) Part 1 - Environment. 66 p. (2006). Risk assessment reports provide scientific support to the development and implementation of EU polices related to health and consumer protection.|European Chemicals Bureau; IUCLID Dataset, 2-Butoxyethyl acetate (112-07-2) (2000 CD-ROM edition) contains information on use, toxicology, and environmental effects of this chemical as supplied to the European Union by industry.|DHHS/ATSDR; Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol acetate (PB/99/102527/AS) (August 1998). The ATSDR toxicological profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is presented in less detail.

Combustible. Above 71 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Warning|H312: Harmful in contact with skin [Warning Acute toxicity, dermal]|P261, P271, P280, P302+P352, P304+P312, P304+P340, P312, P322, P363, and P501|H302+H312+H332 (15.06%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 2929 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|Danger|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P264, P270, P273, P280, P302+P352, P307+P311, P312, P314, P321, P322, P363, P370+P378, P403+P235, P405, and P501|H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]|P260, P264, P270, P307+P311, P309+P311, P314, P321, P405, and P501|P201, P202, P210, P260, P264, P270, P280, P281, P302+P352, P308+P313, P309+P311, P312, P314, P322, P363, P370+P378, P403+P235, P405, and P501

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate chemical protective gloves, boots and goggles.|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Respirator Recommendations: Up to 50 ppm [Table#1248]|For more Personal Protective Equipment (PPE) (Complete) data for ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE (9 total), please visit the HSDB record page.|(See protection codes)

Fire hazard: moderate when exposed to heat, flame or oxidizers.

Above 71 °C explosive vapor/air mixtures may be formed.|Explosive limits, vol% in air: 0.9 (93 °C) - 8.5 (135 °C)|Explosive limits , vol% in air: 0.9 (at 93 °C) - 8.5 (at 135 °C)

Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.|"Alcohol" foam

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.|Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: filter respirator for organic gases and vapors.)

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Personnel protection. Avoid breathing vapors Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Mild skin irritant.|Harmful by inhalation and in contact with skin.

NIOSH recommends reducing exposure to lowest feasible concn & preventing contact with the skin. /Glycol ethers/|Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (33 mg/cu m).

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants and strong bases. Cool. Keep in the dark.

The vapour is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness. The substance may cause effects on the blood. This may result in lesions of blood cells and kidney impairment.

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood. This may result in anaemia and kidney impairment.

NO open flames. Above 71 °C use a closed system and ventilation.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monobutyl ether acetate is produced, as an intermediate or final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

The emission rate of ethylene glycol monobutyl ether acetate into the atmosphere from painting operations at an automotive assembly plant in Janesville, WI was estimated to be 3.5 gallons/hr(1). Samples collected from paint spray booths used in the automotive industry contained ethylene glycol monobutyl ether acetate at unreported concentrations(2).

Ethylene glycol monobutyl ether acetate was detected in 0.4% of 275 solvent products that were sampled in various industry workplaces and analyzed between 1978 and 1982(1); the solvents were commonly used for inks, thinners, degreasers, and paints(1).

LD50 Rat female oral 2400 mg/kg|LD50 Rat male oral 3000 mg/kg|LD50 Rat oral 2,400 mg/kg|LD50 Mouse oral 3,200 mg/kg|For more Non-Human Toxicity Values (Complete) data for ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE (7 total), please visit the HSDB record page.

/AQUATIC SPECIES/ DeVillers et al. (2003) have tested the toxicity of EGBEA on Ceriodaphnia dubia according to the draft of the method AFNOR NF T90-376 (equivalent to the OECD guideline No 211). An EC10 of 30.4 mg/L has been determined after seven days. One daphnid was disposed per container, in ten replicates. The parental mortality and the number of offspring per living parent were used as endpoints. Other test conditions are shown here: eight concentrations plus control were tested at a temperature of 23 +/- 1 °C and pH = 8-9, DO = 8.1-8.3 mg/L and water hardness was 200 +/- 40 mg/L (CaCO3). An analytical monitoring was performed but results were expressed based on nominal concentrations. The 95% confidence interval for the EC10 ranged between 9.89 and 37.73 mg/L. A NOEC (16.4 mg/L) and an EC20 (30.7 mg/L) have also been calculated in another report but methods used for calculation tend to give a preference to the EC10 value.|/AQUATIC SPECIES/ Toxicity tests /in algae. for EGBEA are summarized /in the table/. Test 1 has been performed ... on the algae Scenedesmus subspicatus. The norm DIN 38412/9 was followed. The effects of five concentrations (25, 50, 100, 250 and 500 mg/L) plus one control were measured after 72 and 96 hours. Temperature and pH were respectively 24.8 °C and 7.6-8. No effect was detected at any concentration tested. A NOEC of 300 mg/L was determined in test 2. This test was performed according to the norm ISO 8692: "Water quality - fresh water and algal growth inhibition test with Scenedesmus subspicatus and Selenestrum capricornutum". Test conditions were as follow: incubation occurred on a shaking table under constant temperature (approximately 23 °C) and light. Each test was performed on three replicate batches at each concentration and at each control batch. The cell densities were determined using an electronic particle counter after 24, 48 and 72 hours and the inhibition of growth was estimated as the average growth rate expressed as a percentage of the control growth rate. EC50 was calculated by means of probit analysis and NOEC was determined by using a software (TOXSTAT). It can also be noticed that although the solutions were analysed, toxicity results were based on nominal concentrations.

Ethylene glycol monobutyl ether acetate's production and use as a high-boiling solvent for nitrocellulose lacquers, epoxy resins, multicolor lacquers and as a film coalescing aid for polyvinyl acetate latex(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 9000 mg/L(2) and a regression-derived equation(3), indicates that ethylene glycol monobutyl ether acetate is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol monobutyl ether acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.46X10-6 atm-cu m/mole(4). Ethylene glycol monobutyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.375 mm Hg(5). Biodegradation of ethylene glycol monobutyl ether acetate is expected based on a screening study were 90% was degraded in 28 days(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 9000 mg/L(2) and a regression-derived equation(3), indicates that ethylene glycol monobutyl ether acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 5.46X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 9 and 70 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 4(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives for ethylene glycol monobutyl ether acetate are 300 and 30 days at pHs 7 and 8, respectively(6). Biodegradation of ethylene glycol monobutyl ether acetate is expected based on a screening study were 90% was degraded in 28 days(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monobutyl ether acetate, which has a vapor pressure of 0.375 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monobutyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hrs(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Ethylene glycol monobutyl ether acetate contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of ethylene glycol monobutyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 300 and 30 days at pH values of 7 and 8, respectively(2). Ethylene glycol monobutyl ether acetate contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 4 was calculated in fish for ethylene glycol monobutyl ether acetate(SRC), using a water solubility of 9000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The rate constant for the vapor-phase reaction of ethylene glycol monobutyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 300 and 30 days at pH values of 7 and 8, respectively(2). Ethylene glycol monobutyl ether acetate contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The Henry's Law constant for ethylene glycol monobutyl ether acetate is 5.46X10-6 atm-cu m/mole(1). This Henry's Law constant indicates that ethylene glycol monobutyl ether acetate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 9 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 70 days(SRC). Ethylene glycol monobutyl ether acetate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Ethylene glycol monobutyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.375 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 150,893 workers (38,379 of these were female) were potentially exposed to ethylene glycol monobutyl ether acetate in the US(1). Occupational exposure to ethylene glycol monobutyl ether acetate may occur through inhalation and dermal contact with this compound at workplaces where ethylene glycol monobutyl ether acetate is produced or used. Monitoring and use data indicate that the general population may be exposed to ethylene glycol monobutyl ether acetate via inhalation and dermal contact with products containing ethylene glycol monobutyl ether acetate(SRC).|Ethylene glycol monobutyl ether acetate was given off six new vehicle interiors at an average of 25 ug/hour in new vehicles, 8.6 ug/hr in 20 day old vehicles and 9.5 ug/hour in 40 day old vehicles(1). Ethylene glycol monobutyl ether acetate was detected in the emissions from school books with polyvinyl chloride covers(2).

Individual exposure to 2-butoxyethanol acetate was measured by personal air sampling and biological monitoring of urine from 19 employees during an 8-hour workday in four silk-screen printing installations. The samples were analyzed by gas chromatography. Urine was quantitatively collected from each subject two or three times during the day. 2-Butoxyethanol acetate was detected in the personal air samples of 5 individuals at an average concentration of 0.44 ppm ... The detection limit was 0.015 ppm in air. Free 2-butoxyacetic acid was detected in the urine of 12 individuals, at an average concentration of 8 uM (0.132 mg/L).|Absorption and elimination of dermally applied doses of (14)C-diethylene glycol butyl ether and (14)C-diethylene glycol butyl ether acetate derivative were determined in Sprague-Dawley rats. The materials were applied under occlusion for 24 hr at dose levels of 0.2 and 2.0 g/kg (undiluted) and as a 10% aqueous solution (0.2 g/kg diethylene glycol butyl ether). Preliminary washing efficiency studies with soap and water indicated that greater than 89% of each chemical could be removed from rat skin following 5 min exposures. Female rats excreted a larger proportion of the applied dose of diethylene glycol butyl ether than did male rats. Similar results were obtained with the low dose of diethylene glycol butyl ether applied neat or as a 10% aqueous solution, suggesting that the low dose represents a saturating dose. The total recovered (14)C for all studies with (14)C-diethylene glycol butyl ether ranged from 83% to 89%, with (14)C-diethylene glycol butyl acetate derivative, from 80% to 88%. Urinary excretion accounted for the majority of recovered (14)C in all studies. The acid, 2-(2-butoxyethoxy)acetate acid was the major urinary metabolite identified. The glucuronide of diethylene glycol butyl ether was present at levels of from 5.2 to 8.2% of the urinary (14)C. The dermal absorption rates were estimated to be 1.58 (diethylene glycol butyl acetate derivative, male), 1.28 (diethylene glycol butyl acetate derivative, female), 0.73 (diethylene glycol butyl ether, male), and 1.46 (diethyl glycol butyl ether, female), expressed as mg/cu cm/hr.

... Once absorbed into body, esters are saponified & systemic effect is quite typical of parent glycol or glycol ether. /Ether-esters of glycols/|A study was conducted on 19 employees of four silk screen printing installations, to investigate the usefulness of alkoxyacetic acids in urine as biological indicators of occupational exposure to ethylene glycol ethers. Individual exposures to ethylene glycol ethers were measured by personal air sampling during 1 workday and biological monitoring of urine from these employees. All ethylene glycol ethers air levels were well below the Swedish and American Conference of Governmental Industrial Hygienists threshold limit values. Ethylene glycol monoethyl ether acetate at an average concentration of 5.0 mg/cu m and ethylene glycol monobutyl ether acetate at an average concentration of 2.9 mg/cu m were found in air samples from eight and five subjects, respectively; no ethylene glycol monomethyl ether acetate was found in any air samples. Average urinary levels of methoxyacetic acid, ethoxyacetic acid, and butoxyacetic acid were 6, 80, and 8 uM, respectively.|The metabolism of diethylene glycol monobutyl ether acetate was studied in-vitro and in-vivo. Blood samples from male Sprague-Dawley rats or saline were incubated with 0 or 5 millimolar diethylene glycol butyl acetate derivative for 0 to 14 minutes. Aliquots were taken at various times. The extent of conversion of diethylene glycol butyl acetate derivative to diethylene-glycol-monobutyl-ether was determined. In-vivo, male Sprague-Dawley rats were gavaged with 0, 200, or 2000 mg/kg (14)C labeled diethylene glycol butyl acetate derivative. Urine, feces, and expired air were collected for up to 72 hours and assayed for (14)C activity. The urine samples were analyzed for diethylene glycol butyl acetate derivative metabolites. The rats were killed 72 hours post dosing to determine the tissue distribution of (14)C activity. In-vitro, diethylene glycol monobutyl ether acetate was rapidly hydrolyzed by rat blood to diethylene glycol monobutyl ether; the biological half-life was less than 3 minutes. Only 3.8% of the diethylene glycol monobutyl ether acetate was hydrolyzed by saline after 14 minutes. The urine was the major pathway for eliminating diethylene glycol monobutyl ether acetate derived (14)C activity, 82.3 and 81.3% of the 200 and 2000 mg/kg doses, respectively, being eliminated after 24 hours. Only 2 to 3% of each dose was eliminated in the feces. About 5% of each dose was eliminated in the expired air, mostly as radioactive carbon dioxide. Only about 1.1 and 3.0% of the 200 and 2000 mg/kg doses were found in the tissues and carcass. Most of that radioactivity was found in the carcass. 2-(2-Butoxyethoxy)acetic acid was the major metabolite identified. No unchanged diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether or 2-butoxyacetic acid, a putative hematotoxic diethylene glycol monobutyl ether acetate metabolite, was found. /Results indicate/ that diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether acetate by rat blood. This suggests that the biological effects of diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether would be indistinguishable. No butoxyacetic acid is produced. The data are consistent with the low subchronic toxicity of diethylene glycol monobutyl ether acetate.|Metabolism of 2-butoxyethanol and 2-butoxyethanol acetate to 2-butoxyacetic acid and further metabolism to carbon dioxide is the major pathway of metabolism in both humans and animals. The production of ethylene glycol is a minor pathway of metabolism in both animals and humans.|Absorption and elimination of dermally applied doses of (14)C-diethylene glycol butyl ether and (14)C-diethylene glycol butyl ether acetate derivative were determined in Sprague-Dawley rats. The materials were applied under occlusion for 24 hr at dose levels of 0.2 and 2.0 g/kg (undiluted) and as a 10% aqueous solution (0.2 g/kg diethylene glycol butyl ether). Preliminary washing efficiency studies with soap and water indicated that greater than 89% of each chemical could be removed from rat skin following 5 min exposures. Female rats excreted a larger proportion of the applied dose of diethylene glycol butyl ether than did male rats. Similar results were obtained with the low dose of diethylene glycol butyl ether applied neat or as a 10% aqueous solution, suggesting that the low dose represents a saturating dose. The total recovered (14)C for all studies with (14)C-diethylene glycol butyl ether ranged from 83% to 89%, with (14)C-diethylene glycol butyl acetate derivative, from 80% to 88%. Urinary excretion accounted for the majority of recovered (14)C in all studies. The acid, 2-(2-butoxyethoxy)acetate acid was the major urinary metabolite identified. The glucuronide of diethylene glycol butyl ether was present at levels of from 5.2 to 8.2% of the urinary (14)C. The dermal absorption rates were estimated to be 1.58 (diethylene glycol butyl acetate derivative, male), 1.28 (diethylene glycol butyl acetate derivative, female), 0.73 (diethylene glycol butyl ether, male), and 1.46 (diethyl glycol butyl ether, female), expressed as mg/cu cm/hr.

Purity: the purities were all > or = to 98% w/w. Impurities: ethylene di (acetate) (CAS 111-55-7) < 1% w/w water ~ 0.1% w/w; 2-butoxyethanol (CAS 111-76-2) ~ 0.05% w/w. The remaining 2% or less is very dependent on the purity of the alcohol source and will contain a mixture of alcohols and acetates of homologues. It is thought that there is not any one which is predominant. Additives: It is reported that a food approved antioxidant has been added at a level below that requiring to be declared.

Inhalation of concentrated vapor may cause headache, nausea, dizziness. Liquid causes irritation of eyes and mild irritation of skin. Ingestion produces same symptoms as inhalation. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene glycol, glycols, and related compounds/

/HUMAN EXPOSURE STUDIES/ Individual exposure to 2-butoxyethanol acetate was measured by personal air sampling and biological monitoring of urine from 19 employees during an 8-hour workday in four silk-screen printing installations. The samples were analyzed by gas chromatography. Urine was quantitatively collected from each subject two or three times during the day. 2-Butoxyethanol acetate was detected in the personal air samples of 5 individuals at an average concentration of 0.44 ppm ... The detection limit was 0.015 ppm in air. Free 2-butoxyacetic acid was detected in the urine of 12 individuals, at an average concentration of 8 uM (0.132 mg/L).|/HUMAN EXPOSURE STUDIES/ 2-Butoxyethanol acetate was used to evaluate a noninvasive human method and an in vitro cytotoxicity method as alternatives to the rabbit skin test for primary irritant effects human method included measurements of cutaneous blood flow values (CBFV) by laser Doppler flowmetry before and after patch application on the forearm; some experiments used 100% test substances (75 mg/sq cm) applied for 48 hours and measured 12 hours later, and other experiments used 10% solutions of test substances (7.5 mg/cu m) applied for 3 hours and measured 1, 24, 48, and 72 hours later. Cutaneous blood flow values (CBFV) obtained in the two series of experiments (10% for 3 hours and 100% for 48 hours) resulted in a ranking of 2, which is the minimal mean erythema needed to classify substances as skin irritants. The CBFV in humans correlated very well (r=0.99) with erythema scores obtained on rabbits.|/SIGNS AND SYMPTOMS/ The effects /of alkyl derivatives of ethylene glycol/ ...upon the CNS include headache, drowsiness, weakness, slurred speech, recrudescent stuttering, staggering gait, tremor, and blurred vision. Changes of personality are often noted ...these changes are such that the patient, in the absence of an accurate occupational history, may be treated for schizophrenia or narcolepsy. In acute poisoning with the thylene glycol monoalkyl ethers, there is ...renal injury: albuminuria and hematuria. /Ethylene glycol monoalkyl ethers/|/SIGNS AND SYMPTOMS/ 1. Central nervous depression, although probably less prominent than with ethylene glycol. 2. No hypocalcemic tetany or metabolic acidosis with the possible exception of poisonings due to ethylene glycol monomethyl ether. 3. Nausea, vomiting, and sometimes diarrhea. 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria & then oliguria, progressing to anuria. 6. Acute renal failure ... 7. Less critical pathological lesions may appear in brain, lung, liver, meninges and heart. 8. Observations in animals suggest the remote possibility of pulmonary edema, intravascular hemolysis & bone marrow depression, at least with some ether derivatives of ethylene and diethylene glycols. ... /Ethylene glycol (Group B compounds)/

butylglycol acetate

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, nose, throat; hemolysis, hematuria (blood in the urine); central nervous system depression, headache; vomiting

Cough. Headache. Dizziness. Drowsiness. Nausea.

MAY BE ABSORBED! Redness. Dry skin.

Redness.

Eyes, skin, respiratory system, central nervous system, hematopoietic system, blood, kidneys, liver, lymphoid system

Table: Breakdown of EGBEA Uses in Europe [Table#1247]

Grade: Technical

All other basic organic chemical manufacturing|Ethanol, 2-butoxy-, 1-acetate: ACTIVE

Method: OSHA 83; Procedure: gas chromatography using a flame ionization detector; Analyte: 2-butoxyethyl acetate; Matrix: air; Detection Limit: 24 ppb (157 ug/cu m).|The presence of diethylene glycol monobutyl ether acetate in printing inks was measured using headspace gas chromatograpy with flame ionization detection.

Method: NIOSH 8316, Issue 1; Procedure: gas chromatography with (63)Ni electron capture detector; Analyte: pentafluorobenzyl butoxyacetate, pentafluorobenzyl-butoxyacetic acid; Matrix: urine; Detection Limit: 10 umol/L. /Butoxyacetic acid is a biological indicator of exposure to 2-butoxyethyl acetate/

Fire Hazards -> Flammable - 2nd degree|Cosmetics -> Solvent