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Sevelamer hydrochloride

Sevelamer hydrochloride structure

CAS No:
152751-57-0
Formula:
C6H13Cl2NO
Chemical Name:
Sevelamer hydrochloride
Synonyms:
Sevelemar;Sevelamer Hydrochloride;2-Propen-1-amine - 2-(chloromethyl)oxirane (1:1);Sevelamer-001;2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride;(ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride;2-Propen-1-aMine Hydrochloride polyMer with 2-(ChloroMethyl)oxirane;AllylaMine Hydrochloride-epichlorohydrin CopolyMer
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Sevelamer hydrochloride is an epoxide.|A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

ChEBI: Sevelamer hydrochloride is an epoxide.

Sevelamer hydrochloride Basic Attributes

Molecular Weight：

186.08

Exact Mass：

185.0374194

EC Number：

682-522-4

DSSTox ID：

DTXSID0048630

Color/Form：

Pale Yellow

ATC Code：

V03AE02

Characteristics

Critical Temperature & Pressure：

Store at -20°C

Safety Information

wgk germany：

WGK 3

GHS Classification：

|Warning|H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Renagel is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.Renagel should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.|Tasermity is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis. Sevelamer hydrochloride should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25 dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.,

MeSH：

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

MeSH Entry Terms：

Carbonate, Sevelamer

Sevelamer hydrochloride Use and Manufacturing

Uses

Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.

Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.

Use Classification：

Human drugs -> Renagel -> EMA Drug Category|All other therapeutic products -> Human pharmacotherapeutic group|Human drugs -> Tasermity -> EMA Drug Category|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

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Sevelamer hydrochloride

CAS No.: 152751-57-0

Grade: industrial Grade

Content: 98%

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CAS No.: 152751-57-0

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