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Maxacalcitol

Maxacalcitol structure

CAS No:
103909-75-7
Formula:
C26H42O4
Chemical Name:
Maxacalcitol
Synonyms:
MAXACALCITOL;(1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;(5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol;22-Oxa-1α,25-dihydroxycholecalciferol;Oxacalcitriol;(+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol;1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.

ChEBI: Maxacalcitol is an organic molecular entity.

Maxacalcitol Basic Attributes

Molecular Weight：

418.61

Exact Mass：

418.61

EC Number：

234-317-2

Color/Form：

White to off-white

Characteristics

Density：

1.09±0.1 g/cm3(Predicted)

Melting Point：

122°

Boiling Point：

581.4±50.0 °C(Predicted)

PKA：

14.43±0.40(Predicted)

Critical Temperature & Pressure：

Sealed in dry,Store in freezer, under -20°C

Maxacalcitol Use and Manufacturing

22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.

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