FostaMatinib DisodiuM Hexahydrate
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FostaMatinib DisodiuM Hexahydrate
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CAS No:
914295-16-2
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Formula:
C23H24FN6Na2O9P
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Chemical Name:
FostaMatinib DisodiuM Hexahydrate
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Synonyms:
FostaMatinib DisodiuM Hexahydrate;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one disodium salt hexahydrate;Fostamatinib disodium salt hexahydrate;6-[[5-Fluoro-2-[(3,4,5-triMethoxyphenyl)aMino]-4-pyriMidinyl]aMino]-2,2-diMethyl-4-[(phosphonooxy)Methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one SodiuM Salt Hydrate;R788 (disodiuM hexahydrate);Fostamatinib Na;2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, disodium salt, hexahydrate;R788 Disodium Hexahydrate (Fostamatinib Disodium Hexahydrate)
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CAS No:
Description
Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
FostaMatinib DisodiuM Hexahydrate Basic Attributes
624.4231642
732.17556819
86EEZ49YVB
C69128
White to gray
Safety Information
|Danger|H301 (75%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
FostaMatinib DisodiuM Hexahydrate Use and Manufacturing
A spleen tyrosine kinase inhibitor prodrug for the treatment of inflammatory diseases.
A spleen tyrosine kinase inhibitor prodrug for the treatment of inflammatory diseases. An anti-inflammatory agent.
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