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Phenmetrazine hydrochloride

Phenmetrazine hydrochloride structure

Phenmetrazine hydrochloride 

structure
  • CAS No:

    1707-14-8

  • Formula:

    C11H15NO.ClH

  • Chemical Name:

    Phenmetrazine hydrochloride

  • Synonyms:

    Morpholine,3-methyl-2-phenyl-,hydrochloride (1:1);Morpholine,3-methyl-2-phenyl-,hydrochloride;3-Methyl-2-phenylmorpholine hydrochloride;Phenmetrazine hydrochloride;2-Phenyl-3-methyltetrahydro-1,4-oxazine hydrochloride;Preludin hydrochloride;Preludin;Mefolin;Neo-Zine;Marsine;50-93-1;13425-23-5

Description

Phenmetrazine hydrochloride is an organic molecular entity.|Preludin is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.

Phenmetrazine hydrochloride Basic Attributes

213.704

213.0920418 g/mol

216-950-6

1631

405728

DTXSID0047822

Characteristics

21.3 Ų

182 °C

Safety Information

III

6.1(b)

3249

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

Defenmetrazin

Phenmetrazine|Preludin|1631|Schedule II - Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|No

Phenmetrazine hydrochloride Use and Manufacturing

Methods of Manufacturing

10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.

Uses

Anorexic. Controlled substance (stimulant).

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:213.70
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:213.0920418
Monoisotopic Mass:213.0920418
Topological Polar Surface Area:21.3
Heavy Atom Count:14
Complexity:154
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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