1,2,3,4-Tetrachlorodibenzo-p-dioxin

321.97

321.97

HF5S8P28CC

2811

DTXSID7074030

18.5 Ų

6.6 (LogP)

1.6430 (estimate)

188 °C

407.62°C (rough estimate)

1.6430 (estimate)

0.55ug/L(25 ºC)

4.80e-08 mmHg

8.50e-13 cm3/molecule*sec

2.00e-05 atm-m3/mole

Insoluble in water.

Ethers

This type of compound is extremely stable, even on heating to 1292° F. Solutions of this type of chemical in methanol are degraded by exposure to summer sunlight or irradiation with an ultraviolet lamp (300 nm). (NTP, 1992).

I

6.1(a)

2811

Flash point data for this compound are not available; however, it is probably combustible. (NTP, 1992)

|Warning|H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: This chemical should be stored at ambient temperatures and protected from light. Allow only your most experienced personnel access to this aliquot. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

2.88e+03

10.47 Days

SYMPTOMS: Ingestion, inhalation and skin contact to this class of compounds has caused chloracne which is characterized by comedones, keratin cysts, pustules, papules and abscesses. This may clear in a few months or persist for up to 15 years. Symptoms may occur weeks or months after initial exposure. Exposure to a related compound has caused endocrine, immunologic, hematologic, gastrointestinal and neuropsychiatric effects. Other symptoms include a burning sensation in the eyes, nose and throat; headache, dizziness, nausea, vomiting, arthralgias, extreme fatigue, insomnia, loss of libido, irritability, nervousness, high levels of cholesterol, hyperlipoproteinaemia, porphyria cutanea tarda, hepatic dysfunction, hyperpigmentation, hirsuitism, disorders of the cardiovascular, urinary, respiratory and pancreatic systems; disorders of fat and carbohydrate metabolism, emotional disorders, difficulties with muscular and mental coordination, blurred vision and loss of taste and smell. Itching, swelling and redness of the face may occur just prior to the appearance of chloracne. Other symptoms include muscular weakness, loss of appetite and weight, sleep disturbances, orthostatic hypotension, abdominal pain and liver impairment. It may also cause liver and kidney damage and personality changes. ACUTE/CHRONIC HAZARDS: This compound is extremely toxic. Ingestion of very small quantities can cause toxic effects. It may also be absorbed through the skin. Allow only your most experienced personnel to work with this chemical. All nonessential personnel should leave the laboratory. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

1,2,3,4-TCDD