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FLAVOKAVAIN A(P)

FLAVOKAVAIN A(P) structure

CAS No:
37951-13-6
Formula:
C18H18O5
Chemical Name:
FLAVOKAVAIN A(P)
Synonyms:
FLAVOKAVAIN A(P);(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one;Flavokavain A;(E)-Flavokawain A;2-Propen-1-one,1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-, (2E)-;inhibit,Inhibitor,(E) Flavokawain A,(E)Flavokawain A,(E)-Flavokawain A,Apoptosis;Flavokawain A-RM;(E)-Flavokawain A, 10 mM in DMSO
Categories:
Natural Products > Lignans

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Description

Solid

Flavokawain A is a member of chalcones.

FLAVOKAVAIN A(P) Basic Attributes

Molecular Weight：

314.33

Exact Mass：

314.33

NSC Number：

37445

Color/Form：

Light yellow to yellow

Characteristics

PSA：

64.99000

XLogP3：

3.31410

Density：

1+-.0.06 g/cm3(Predicted)

Melting Point：

113-114℃

Boiling Point：

529.9±50.0 °C(Predicted)

Water Solubility：

10.02 mg/L @ 25 °C (est)

PKA：

6.88±0.40(Predicted)

Critical Temperature & Pressure：

4°C, protect from light

Safety Information

wgk germany：

WGK 3

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

flavokavin A

FLAVOKAVAIN A(P) Use and Manufacturing

Flavokawain A is achalcone found in the kava plant. It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway. Furthermore, natural chalcones have beenimplicated as lead compounds for developing dual inhibitors againsthistone deacetylase enzymes (HDACs)and NF-κB.

Computed Properties

Molecular Weight:314.3
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:314.11542367
Monoisotopic Mass:314.11542367
Topological Polar Surface Area:65
Heavy Atom Count:23
Complexity:400
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of FLAVOKAVAIN A(P)

Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

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Trader Supplier of Apigenin,PQQ,NMNH

Flavokawain

Unit Price: $10 /G EXW

CAS No.: 37951-13-6

Grade: Pharmaceutical grade

Content: 99%

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Guide of FLAVOKAVAIN A(P)

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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