HPI-4,HedgehogPathwayInhibitor4
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HPI-4,HedgehogPathwayInhibitor4
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CAS No:
302803-72-1
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Formula:
C17H9Cl2N3O2
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Chemical Name:
HPI-4,HedgehogPathwayInhibitor4
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Synonyms:
HPI-4;HPI-4,Hedgehog Pathway Inhibitor 4;Ciliobrevin A;Ciliobrevin A(HPI4);2-(7-Chloro-4-oxo-3,4-dihydro-1H-quinazolin-2-ylidene)-3-(2,4-dichloro-phenyl)-3-oxo-propionitrile;(Z)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile;2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-benzenepropanenitrile;Hedgehog Pathway Inhibitor 4
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CAS No:
Safety Information
UN 3077 9 / PGIII
3
22-50/53
60-61
Xn,N
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
HPI-4,HedgehogPathwayInhibitor4 Use and Manufacturing
Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.
Computed Properties
Molecular Weight:358.2
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:357.0071819
Monoisotopic Mass:357.0071819
Topological Polar Surface Area:85.5
Heavy Atom Count:24
Complexity:637
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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