(NAPHTHALEN-2-YLAMINO)-ACETICACID(3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
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(NAPHTHALEN-2-YLAMINO)-ACETICACID(3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
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CAS No:
328541-79-3
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Formula:
C19H15Br2N3O3
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Chemical Name:
(NAPHTHALEN-2-YLAMINO)-ACETICACID(3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
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Synonyms:
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE;GLYH-101;Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide;N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101
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CAS No:
(NAPHTHALEN-2-YLAMINO)-ACETICACID(3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE Basic Attributes
493.15
492.94597
(NAPHTHALEN-2-YLAMINO)-ACETICACID(3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE Use and Manufacturing
N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.
Computed Properties
Molecular Weight:493.1
XLogP3:4.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:492.94597
Monoisotopic Mass:490.94802
Topological Polar Surface Area:94
Heavy Atom Count:27
Complexity:536
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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