Muraglitazar
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Muraglitazar
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CAS No:
331741-94-7
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Formula:
C29H28N2O7
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Chemical Name:
Muraglitazar
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Synonyms:
Glycine,N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-;N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine;BMS 298585;Muraglitazar;Pargluva
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CAS No:
Description
Muraglitazar (Bristol-Myers Squibb/Merck) is a new agent under investigation for the treatment of patients with type 2 diabetes. It belongs to a novel class of drugs that target the peroxisome proliferator-activated receptors, both alpha and gamma subtypes. In addition to improvements in blood glucose and hemoglobin A1c (HbA1c), muraglitazar treatment is associated with a substantial reduction in triglycerides (TGs), an increase in HDL-C, and a modest decrease in LDL-C levels.|Muraglitazar is a dual peroxisome proliferator-activated receptor (PPAR) agonist, with hypoglycemic activity. Muraglitazar causes an increase in HDL-C levels, and a decrease in total cholesterol, apolipoprotein B, triglycerides and HbA1c. This agent is associated with an increased risk of adverse cardiovascular events and heart failure.
Characteristics
111 Ų
1.274±0.06 g/cm3
139.1-140.2 °C @ Solvent: Ethanol
736.4±70.0 °C(Predicted)
3.82±0.10
Drug Information
Investigated for use/treatment in diabetes mellitus type 2.
Muraglitazar has known human metabolites that include 12-Hydroxy muraglitazar, 17-Hydroxy muraglitazar, 9-Hydroxy muraglitazar, N-((4-Hydroxyphenyl)methyl)-N-((4-methoxyphenoxy)carbonyl)glycine, and O-Demethyl muraglitazar.
Muraglitazar is one of the dual peroxisome proliferator-activated receptor (PPAR) agonists. It interacts with both PPAR alpha and gamma receptors. Working through the PPAR gamma receptor, muraglitazar has very potent insulin-sensitizing effects on liver and muscle to lower the blood sugar levels. working through the PPAR alpha receptor, muraglitazar is very potent in terms of lowering the triglycerides and raising the HDL [high-density lipoprotein] cholesterol and converting small dense LDL [low-density lipoprotein] particles to larger, more buoyant particles, so it promotes a very good lipid profile from the standpoint of prevention of atherosclerosis.
BMS 298585
Muraglitazar Use and Manufacturing
It is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist.
Computed Properties
Molecular Weight:516.5
XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:516.18965124
Monoisotopic Mass:516.18965124
Topological Polar Surface Area:111
Heavy Atom Count:38
Complexity:730
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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