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Toceranib

Toceranib structure

CAS No:
356068-94-5
Formula:
C22H25FN4O2
Chemical Name:
Toceranib
Synonyms:
1H-Pyrrole-3-carboxamide,5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-;5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide;5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-(pyrrolidin-1-yl)ethyl)amide;SU 11654;Toceranib;PHA 291639;Palladia
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Toceranib Basic Attributes

Molecular Weight：

396.46

Exact Mass：

396.46

UNII：

59L7Y0530C

DSSTox ID：

DTXSID50189076

ATC Code：

QL01EX90

Characteristics

PSA：

77.23000

XLogP3：

3.55570

Density：

1.293

Boiling Point：

596.8±50.0 °C(Predicted)

PKA：

11.70±0.20

Drug Information

Drug Indication：

Treatment of non-resectable Patnaik grade-II (intermediate-grade) or -III (high-grade), recurrent, cutaneous mast-cell tumours in dogs.

MeSH Entry Terms：

palladia

Toceranib Use and Manufacturing

Uses

Labelled Toceranib, a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor. Toceranib exhibited activity against a variety of spontaneous malignancies in canine such as mast cell tumors, mixed mammary carcinomas, soft tissue sarcomas, and multiple myeloma.

Use Classification：

Veterinary drugs -> Palladia -> EMA Drug Category|Antineoplastic agents -> Veterinary pharmacotherapeutic group

Computed Properties

Molecular Weight:396.5
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:396.19615422
Monoisotopic Mass:396.19615422
Topological Polar Surface Area:77.2
Heavy Atom Count:29
Complexity:663
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Toceranib

CAS No.: 356068-94-5

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