Toceranib
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Toceranib
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CAS No:
356068-94-5
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Formula:
C22H25FN4O2
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Chemical Name:
Toceranib
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Synonyms:
1H-Pyrrole-3-carboxamide,5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-;5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide;5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-(pyrrolidin-1-yl)ethyl)amide;SU 11654;Toceranib;PHA 291639;Palladia
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CAS No:
Drug Information
Treatment of non-resectable Patnaik grade-II (intermediate-grade) or -III (high-grade), recurrent, cutaneous mast-cell tumours in dogs.
palladia
Toceranib Use and Manufacturing
Labelled Toceranib, a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor. Toceranib exhibited activity against a variety of spontaneous malignancies in canine such as mast cell tumors, mixed mammary carcinomas, soft tissue sarcomas, and multiple myeloma.
Veterinary drugs -> Palladia -> EMA Drug Category|Antineoplastic agents -> Veterinary pharmacotherapeutic group
Computed Properties
Molecular Weight:396.5
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:396.19615422
Monoisotopic Mass:396.19615422
Topological Polar Surface Area:77.2
Heavy Atom Count:29
Complexity:663
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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