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Milbemycin D

Milbemycin D structure

CAS No:
77855-81-3
Formula:
C33H48O7
Chemical Name:
Milbemycin D
Synonyms:
Milbemycin B,5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-,(6R,25R)-;Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran],milbemycin B deriv.;(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)milbemycin B;Antibiotic B 41D;Milbemycin D;86090-81-5
Categories:
Organic Chemistry > Lactones

Description

Milbemycin D is a milbemycin originally isolated from Streptomyces hygroscopicus with formula C33H48O7 that has insecticidal and anthelmintic proerties. It has a role as an insecticide, an anthelminthic drug and a nematicide.

Milbemycin D Basic Attributes

Molecular Weight：

556.73

Exact Mass：

556.73

UNII：

04S0E2XJQI

Characteristics

PSA：

94.45000

XLogP3：

5.17030

Density：

1.0367

Melting Point：

186-188°

Boiling Point：

460.61°C (rough estimate)

Refractive Index：

1.5300 (estimate)

Drug Information

MeSH：

Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)|Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)|Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

MeSH Entry Terms：

5-hydroxymilbemycin beta7

Milbemycin D Use and Manufacturing

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin D is a minor member of a group of analogues containing a 25-isopropyl substituent. Milbemycin D is a highly selective and potent nematocide and insecticide. Like the closely related avermectin, milbemycins are thought to act on chloride-gated ion channels.

Computed Properties

Molecular Weight:556.7
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:556.34000387
Monoisotopic Mass:556.34000387
Topological Polar Surface Area:94.4
Heavy Atom Count:40
Complexity:1090
Defined Atom Stereocenter Count:10
Defined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes