4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol
-
4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol
structure -
-
CAS No:
734517-40-9
-
Formula:
C25H27ClN2O
-
Chemical Name:
4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol
-
Synonyms:
1-Piperazineethanol,4-(3-chlorophenyl)-α-(diphenylmethyl)-;4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol
-
CAS No:
Description
3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol is an N-alkylpiperazine that is 1-(3-chlorophenyl)piperazine carrying a 3,3-diphenyl-2-hydroxyprop-1-yl group at position 4. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types. It has a role as a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a N-arylpiperazine, a secondary alcohol and a member of monochlorobenzenes. It is a conjugate base of a 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+).
4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol Basic Attributes
406.95
406.95
LY8CZE6XUD
DTXSID4043983
Drug Information
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes. (See all compounds classified as Serotonin 5-HT1 Receptor Antagonists.)
3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenyl-2-propanol
Computed Properties
Molecular Weight:406.9
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:406.1811912
Monoisotopic Mass:406.1811912
Topological Polar Surface Area:26.7
Heavy Atom Count:29
Complexity:451
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Request for Quotation