 Home > Encyclopedia > Dorsomorphin

Dorsomorphin

Dorsomorphin structure

CAS No:
866405-64-3
Formula:
C24H25N5O
Chemical Name:
Dorsomorphin
Synonyms:
Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-;6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine;Dorsomorphin;Compound C;6-[4-(2-Piperidine-1-ylethoxy)phenyl]-3-pyridine-4-ylpyrazolo[1,5-a]pyrimidine
Categories:
Specialty Chemicals

Description

Dorsomorphin is a pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. It has a role as an EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor and a bone morphogenetic protein receptor antagonist. It is a pyrazolopyrimidine, a member of piperidines, an aromatic ether and a member of pyridines.

Dorsomorphin Basic Attributes

Molecular Weight：

399.49

Exact Mass：

399.49

UNII：

10K52CIC1Z

HScode：

2933990090

Characteristics

PSA：

55.55000

XLogP3：

4.26090

Density：

1.25±0.1 g/cm3

Refractive Index：

1.67

Storage Conditions：

2-8ºC

PKA：

8.53±0.10

Safety Information

wgk germany：

hazard class code：

20/21/22

safety instructions：

36/37

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302; H312; H332

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

MeSH Entry Terms：

(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine

Dorsomorphin Use and Manufacturing

A potent inhibitor of AMPK and fatty acid biosynthesis.

Computed Properties

Molecular Weight:399.5
XLogP3:3.4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:399.20591044
Monoisotopic Mass:399.20591044
Topological Polar Surface Area:55.6
Heavy Atom Count:30
Complexity:514
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Dorsomorphin

Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

BML-275 99% high quality see COA KANBEI

CAS No.: 866405-64-3

Grade: Industrial Grade

Content: 99%

Inquiry