PhiKan-083Hydrochloride
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PhiKan-083Hydrochloride
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CAS No:
880813-36-5
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Formula:
C16H18N2
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Chemical Name:
PhiKan-083Hydrochloride
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Synonyms:
PhiKan-083 Hydrochloride;PhiKan 083;[(9-Ethyl-9H-carbazol-3-yl)methyl](methyl)amine;9-Ethyl-N-methyl-carbazole-3-methanamine;PK083;9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride;9H-Carbazole-3-methanamine, 9-ethyl-N-methyl-
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
PhiKan-083Hydrochloride Use and Manufacturing
PhiKan-083 is a p53 stabilizing agent. PhiKan-083 preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan-083 slows rate of thermal denaturation of p53-Y220C.
Computed Properties
Molecular Weight:238.33
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:238.146998583
Monoisotopic Mass:238.146998583
Topological Polar Surface Area:17
Heavy Atom Count:18
Complexity:278
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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