Lactacystin
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Lactacystin
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CAS No:
133343-34-7
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Formula:
C15H24N2O7S
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Chemical Name:
Lactacystin
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Synonyms:
L-Cysteine,N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-;L-Cysteine,N-acetyl-,3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester),[2R-[2α,2(S*),3α,4α]]-;L-Cysteine,N-acetyl-,(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester);N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine;Lactacystin;(+)-Lactacystin
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CAS No:
Characteristics
178.33000
-0.56230
White to off-white powder.
1.367±0.06 g/cm3
233-235 °C (decomp)
714.9±60.0 °C(Predicted)
386.1ºC
1.559
-20ºC
1.31E-23mmHg at 25°C
3.11±0.10
Lactacystin Use and Manufacturing
A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex)
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