iCRT14
-
iCRT14
structure -
-
CAS No:
677331-12-3
-
Formula:
C21H17N3O2S
-
Chemical Name:
iCRT14
-
Synonyms:
iCRT 14;5-[[2,5-DiMethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]Methylene]-3-phenyl-2,4-thiazolidinedione;(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione;CS-1225;ICRT14;ICRT-14;2,4-Thiazolidinedione, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-;iCRT 14 (Fandachem)
-
CAS No:
Drug Information
5-((2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl)methylene)-3-phenyl-2,4-thiazolidinedione
iCRT14 Use and Manufacturing
A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Computed Properties
Molecular Weight:375.4
XLogP3:4.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:375.10414797
Monoisotopic Mass:375.10414797
Topological Polar Surface Area:80.5
Heavy Atom Count:27
Complexity:617
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes