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trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol structure

CAS No:
193551-21-2
Formula:
C20H21FN4O2
Chemical Name:
trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
Synonyms:
Cyclohexanol,4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-,trans-;trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol;SB 239063;BRD-K 98143437

Description

SB-239063 is a member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of cyclohexanols, a member of imidazoles, a member of pyrimidines, an aromatic ether, a member of monofluorobenzenes and a secondary alcohol.

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol Basic Attributes

Molecular Weight：

368.4

Exact Mass：

368.40

UNII：

HII3DC8CPI

DSSTox ID：

DTXSID90274455

Characteristics

PSA：

73.06000

XLogP3：

3.63080

Density：

1.35g/cm3

Melting Point：

206-207.2 °C

Boiling Point：

594.8ºC

Flash Point：

313.5ºC

Refractive Index：

1.655

Vapor Pressure：

5.42E-15mmHg at 25°C

Safety Information

wgk germany：

safety instructions：

22-24/25

RTECS Number：

GV9458000

Drug Information

MeSH：

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

MeSH Entry Terms：

SB 239063

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol Use and Manufacturing

SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. A protein kinase inhibitor

Computed Properties

Molecular Weight:368.4
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:368.16485409
Monoisotopic Mass:368.16485409
Topological Polar Surface Area:73.1
Heavy Atom Count:27
Complexity:469
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

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