Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate
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![Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/eaf24e5d552a4cbabaa21f0864b20a21.png "Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate")
Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate
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CAS No:
133208-93-2
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Formula:
C19H20BrN2O4P
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Chemical Name:
Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate
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Synonyms:
Phosphonic acid,[[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-,diethyl ester;Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate;NO 1886;Ibrolipim;OPF 009
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CAS No:
Description
Ibrolipim is a lipoprotein lipase (LPL) activator with antihyperlipidemic activity. Activation of LDL by ibrolipim lowers plasma triglycerides, with a concomitant elevation of high-density lipoprotein cholesterol.
Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate Basic Attributes
451.25
451.25
07H1561618
DTXSID20157989
C75256
Safety Information
UN 2811 6.1 / PGIII
3
36/37/38-25
26-36-45
Xi,T
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds that increase the enzymatic activity of LIPOPROTEIN LIPASE. Lipoprotein lipase activators have a potential role in the treatment of OBESITY by increasing LIPID METABOLISM. Note that substances that increase the synthesis of lipoprotein lipase are not included here. (See all compounds classified as Lipoprotein Lipase Activators.)|Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)
Ibrolipim has known human metabolites that include [4-[(4-Bromo-2-cyanophenyl)carbamoyl]phenyl]methyl-ethoxyphosphinic acid.
4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide
Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate Use and Manufacturing
Antiatherogenic; antiobesity; antidyslipidemia; anticachexia; and antidiabetes/syndrome.
Computed Properties
Molecular Weight:451.2
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:450.03441
Monoisotopic Mass:450.03441
Topological Polar Surface Area:88.4
Heavy Atom Count:27
Complexity:576
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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