Dexpramipexole
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Dexpramipexole
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CAS No:
104632-28-2
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Formula:
C10H17N3S
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Chemical Name:
Dexpramipexole
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Synonyms:
2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(6R)-;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(R)-;(6R)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine;R-(+)-Pramipexole;(R)-Pramipexole;(R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine;Dexpramipexole;(R)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole;(6R)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;(6R)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
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CAS No:
Description
Dexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)).|A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.
Drug Information
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)|Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)
2 Amino 6 propylaminotetrahydrobenzothiazole
Dexpramipexole Use and Manufacturing
The opposite enantiomer of Pramipexole (P700755), harmacokinetics.
Computed Properties
Molecular Weight:211.33
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:211.11431873
Monoisotopic Mass:211.11431873
Topological Polar Surface Area:79.2
Heavy Atom Count:14
Complexity:188
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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