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Rusfertide

Rusfertide structure

CAS No:
1628323-80-7
Formula:
C114H181N27O28S2
Chemical Name:
Rusfertide
Synonyms:
UNII-XM71MYX0IQ;XM71MYX0IQ;PTG-300;Rusfertide;Rusfertide [USAN];PTG-300FB;WHO 11456;1628323-80-7;Isovaleryl-Asp-Thr-His-Phe-Pro-cyclo(Cys-Ile-Lys(palm-gamma-Glu)- Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys)-Lys-NH2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Rusfertide is an injectable peptide mimetic of hepcidin (hepcidin antimicrobial peptide; HAMP; putative liver tumor regressor; PLTR; liver-expressed antimicrobial peptide 1; LEAP-1) with potential use in the treatment of iron deficiency anemia and iron overload secondary to hematologic disorders. Upon administration, rusfertide mimics endogenous hepcidin, a protein primarily produced in hepatocytes, and increases hepcidin levels. As hepcidin plays a key role in the homeostasis of systemic iron, rusfertide may serve to normalize iron levels. Low levels of endogenous hepcidin are associated with iron overload secondary to excessive absorption of iron as seen in beta thalassemia and paradoxically with iron deficiency anemia.

Rusfertide Basic Attributes

Molecular Weight：

2442.0 g/mol

Exact Mass：

2441.3044354 g/mol

UNII：

XM71MYX0IQ

NCI Thesaurus Code：

C162883

Characteristics

PSA：

924 Å²

Computed Properties

Molecular Weight:2442.0
XLogP3:-1.5
Hydrogen Bond Donor Count:29
Hydrogen Bond Acceptor Count:34
Rotatable Bond Count:67
Exact Mass:2441.3044354
Monoisotopic Mass:2440.3010806
Topological Polar Surface Area:924
Heavy Atom Count:171
Complexity:5090
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Rusfertide

Qingdao Orient Chemical Co.,LTD Contact Supplier

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1 YR

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cerebrolysin peptide collaboration

Unit Price: $80 /UNIT FOB

CAS No.: 1628323-80-7

Grade: Industrial Grade

Content: 98%

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