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Bucindolol

Bucindolol structure

CAS No:
71119-11-4
Formula:
C22H25N3O2
Chemical Name:
Bucindolol
Synonyms:
Benzonitrile,2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-;2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile;Bucindolol;MJ 13105-1;DL-Bucindolol;2-[2-Hydroxy-3-[[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino]propoxy]benzonitrile;111671-41-1;91476-02-7
Categories:
Organic Chemistry > Amides

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Description

Bucindolol has been investigated in Heart Failure.

Bucindolol Basic Attributes

Molecular Weight：

363.45300

Exact Mass：

363.45

EC Number：

615-251-7

DSSTox ID：

DTXSID3046744

Characteristics

PSA：

81.07000

XLogP3：

3.78108

Density：

1.21g/cm3

Boiling Point：

605.3ºC at 760 mmHg

Flash Point：

319.9ºC

Refractive Index：

1.632

Storage Conditions：

Store at +4ºC

Drug Information

MeSH：

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

MeSH Entry Terms：

bucindolol

Computed Properties

Molecular Weight:363.5
XLogP3:3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:363.19467705
Monoisotopic Mass:363.19467705
Topological Polar Surface Area:81.1
Heavy Atom Count:27
Complexity:515
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes