2-Hydroxydesipramine
-
2-Hydroxydesipramine
structure -
-
CAS No:
1977-15-7
-
Formula:
C18H22N2O
-
Chemical Name:
2-Hydroxydesipramine
-
Synonyms:
5H-Dibenz[b,f]azepin-2-ol,10,11-dihydro-5-[3-(methylamino)propyl]-;10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol;GP 36329;2-Hydroxydesmethylimipramine;2-Hydroxydesipramine;2-Hydroxydemethylimipramine;112663-90-8
-
CAS No:
Characteristics
35.50000
3.69430
1.117g/cm3
146-148ºC
477.9ºC at 760mmHg
242.8ºC
1.596
9.32E-10mmHg at 25°C
Drug Information
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)
2-hydroxy-desipramine is a known human metabolite of Desipramine.
2-hydroxy-desipramine
Computed Properties
Molecular Weight:282.4
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:282.173213330
Monoisotopic Mass:282.173213330
Topological Polar Surface Area:35.5
Heavy Atom Count:21
Complexity:322
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes