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(+)-Flurbiprofen

(+)-Flurbiprofen structure

CAS No:
51543-39-6
Formula:
C15H13FO2
Chemical Name:
(+)-Flurbiprofen
Synonyms:
[1,1′-Biphenyl]-4-acetic acid,2-fluoro-α-methyl-,(αS)-;[1,1′-Biphenyl]-4-acetic acid,2-fluoro-α-methyl-,(S)-;(αS)-2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic acid;d-Flurbiprofen;(+)-Flurbiprofen;S-(+)-Flurbiprofen;(S)-Flurbiprofen;(+)-(S)-Flurbiprofen;Esflurbiprofen;(2S)-2-(2-Fluoro-1,1′-biphenyl-4-yl)propanoic acid;(2S)-2-(2-Fluoro-4-biphenyl)propanoic acid;Dexflurbiprofen;(S)-2-(2-Fluorobiphenyl-4-yl)propanoic acid;(S)-2-(2-Fluoro-[1,1′-biphenyl]-4-yl)propanoic acid;(2S)-2-(2-Fluoro-1,1′-biphenyl-4-yl)propanoic acid;(S)-2-(2-Fluoro-[1,1′-biphenyl]-4-yl)propanoicacid
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

(S)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (R)-flurbiprofen.|Esflurbiprofen is under investigation in clinical trial NCT03434197 (Safety and Efficacy of SFPP in Knee Osteoarthritis).

(+)-Flurbiprofen Basic Attributes

Molecular Weight：

244.26100

Exact Mass：

244.26

EC Number：

257-263-1

UNII：

J5ZZK9P7MX

NSC Number：

685700

ATC Code：

M - Musculo-skeletal system

Characteristics

PSA：

37.30000

XLogP3：

3.68080

Appearance：

White to yellowish crystalline powder

Density：

1.199g/cm3

Melting Point：

115-117 °C

Boiling Point：

376.2ºC at 760 mmHg

Flash Point：

181.3ºC

Refractive Index：

1.567

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

R25

safety instructions：

36/37/39-45

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

Metabolism/Metabolites：

(s)-flurbiprofen has known human metabolites that include 4-hydroxy-S-flurbiprofen.

Computed Properties

Molecular Weight:244.26
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:244.08995782
Monoisotopic Mass:244.08995782
Topological Polar Surface Area:37.3
Heavy Atom Count:18
Complexity:286
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 51543-39-6

Grade: Pharmaceutical Grade

Content: 99%

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