rac-Tenofovir-d7
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rac-Tenofovir-d7
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CAS No:
107021-12-5
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Formula:
C9H14N5O4P
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Chemical Name:
rac-Tenofovir-d7
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Synonyms:
rac Tenofovir;9-(2-Phosphonomethoxypropyl)adenine;Tenofovir Impurity 84(rac-Tenofovir);Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-;rac-Tenofovir D7Q: What is rac-Tenofovir D7 Q: What is the CAS Number of rac-Tenofovir D7;D7-rac-Tenofovir
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CAS No:
Description
An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
Characteristics
146.19000
0.53000
1.79±0.1 g/cm3(Predicted)
616.1±65.0 °C(Predicted)
326.4ºC
1.739
4.92E-16mmHg at 25°C
2.36±0.10(Predicted)
Drug Information
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)
(R)-9-(2-phosphonylmethoxypropyl)adenine
rac-Tenofovir-d7 Use and Manufacturing
rac Tenofovir is the unlabeled form of rac Tenofovir-13C5 (>90%) (T018501), which is is the isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.
Computed Properties
Molecular Weight:287.21
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:287.07834094
Monoisotopic Mass:287.07834094
Topological Polar Surface Area:136
Heavy Atom Count:19
Complexity:354
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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