 Home > Encyclopedia > Tenofovir

Tenofovir

Tenofovir structure

CAS No:
107021-12-5
Formula:
C9H14N5O4P
Chemical Name:
Tenofovir
Categories:
Organic Chemistry > Phosphines

Description

An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

Tenofovir Basic Attributes

Molecular Weight：

287.21200

Exact Mass：

287.07834094 g/mol

DSSTox ID：

DTXSID00648805

Characteristics

PSA：

146.19000

XLogP3：

0.53000

Density：

1.79g/cm3

Boiling Point：

616.1ºC at 760mmHg

Flash Point：

326.4ºC

Refractive Index：

1.739

Vapor Pressure：

4.92E-16mmHg at 25°C

Drug Information

MeSH：

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)

MeSH Entry Terms：

(R)-9-(2-phosphonylmethoxypropyl)adenine

Computed Properties

Molecular Weight:287.21
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:287.07834094
Monoisotopic Mass:287.07834094
Topological Polar Surface Area:136
Heavy Atom Count:19
Complexity:354
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes