Sodium arsenate heptahydrate

312.01400

311.962569 g/mol

90ZQ7G407W

0326

1685

DTXSID3032048

Colorless, monoclinic crystals

148.03000

-1.74430

white or colourless crystals

1.9 g/cm³

130 °C

356 °F at 760 mm Hg (decomposes) (NTP, 1992)

Index of refraction: 1.462, 1.466 & 1.478

greater than or equal to 100 mg/mL at 77° F (NTP, 1992)|5.46 g/100 cc water @ 0 °C; 100 g/100 cc water @ 100 °C; sol in glycerol|Solubility in water, g/100ml at 21 °C: 39

Odorless

Decomposes at 180 °C

Effloresces in warm air. Water soluble.

Salts, Basic

SODIUM ARSENATE HEPTAHYDRATE is incompatible with strong oxidizing agents and strong acids. Also incompatible with iron, aluminum and zinc in the presence of water. (NTP, 1992). Sodium arsenate heptahydrate is a weak oxidizing agent, and may react with strong or weak reducing agents.

II

6.1

UN 1685 6.1/PG 2

3

R45; R23/25; R50/53

S53; S45; S60; S61

CG0900000

T; N

Stable. Incompatible with strong reducing agents, strong oxidizing agents, strong acids. Incompatible with iron, aluminium and zinc in the presence of water.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Storage: Sodium is precipitated as hydroxides by using an excess of lime water, and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal. The following storage possibilities are available today for arsenic residues that cannot be recycled immediately or at all: 1) special dumps sealed against the penetration of ground water, surface water and rain water; 2) galleries in abandoned salt mines; 3) concrete silos. In any case the sludge must be dewatered beforehand until it is compact. Recommendable methods: Precipitation, solidification, landfill. Not recommendable methods: Thermal destruction, discharge to sewer. Peer-review: Soluble arsenic cmpd should be converted to the insoluble sulfide before solidification. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) on Arsenic, inorganic (7440-38-2).[Available from the Substance File List as of March 15, 2000: http://www.epa.gov/iris/subst/index.html]|IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Volume 84 (2004). Some Drinking-water Disinfectants and Contaminants, including Arsenic.[Available from, as of July 22, 2009: http://monographs.iarc.fr/ENG/Monographs/vol84/volume84.pdf]|National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Inorganic Arsenic Compounds are listed as known to be human carcinogens. /Arsenic Compounds, Inorganic/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s015arse.pdf]

Literature sources indicate that this chemical is nonflammable. (NTP, 1992)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion on contact with metals. See Chemical Dangers.

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P281, P301+P310, P304+P340, P308+P313, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)|In case of fire in the surroundings, use appropriate extinguishing media.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical at ambient temperatures, and keep it away from oxidizing materials and acids. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Store in an area without drain or sewer access. Well closed. Separated from acids and food and feedstuffs.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cardiovascular system, central nervous system, gastrointestinal tract and kidneys. This may result in cardiac disorders, severe gastroenteritis, loss of fluids and electrolytes, kidney impairment, collapse and shock. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the peripheral nervous system, mucous membranes, skin, cardiovascular system, bone marrow, kidneys and liver. This may result in neuropathy, pigmentation disorders, perforation of the nasal septum, lesions of blood cells, kidney impairment and cirrhosis. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use closed system or ventilation.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection if powder.

CERCLA requires that the person in charge of a vessel or facility notify the National Response Center immediately when there is a release of sodium arsenate in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free telephone number of the NRC is (800) 424-8802; in the Washington metropolitan area (202) 42-2675. The rule for determining when notification is required is stated in 40 CFR 302.6 (see section D.3.b). [50FR 13 456 (4/14/85)] /Sodium arsenate/

DNA inhibition human cell types other than lymphocyte 10 umol/l /Disodium arsenate/|DNA inhibition human lymphocyte 100 nmol/l /Disodium arsenate/|Cytogenetic analysis human leukocyte 7200 nmol/l /Disodium arsenate/|Cytogenetic analysis human lymphocyte 500 nmol/l /Disodium arsenate/|Sister chromatid exchange human lymphocyte 2500 ug/l /Disodium arsenate/

Unscheduled DNA synthesis Escherichia coli 130 ug/well /Disodium arsenate/|Gene conversion and mitotic recombination Bacillis subtilis 100 mmol/l /Disodium arsenate/|Microsomal mutagenicity assay mouse lymphocyte 18 mg/l /Disodium arsenate/|Oncogenic transformation hamster embryo 2500 ug/l /Disodium arsenate/|For more Non-Human Toxicity Values (Complete) data for DISODIUM ARSENATE HEPTAHYDRATE (6 total), please visit the HSDB record page.

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

Arsenate has long been known to uncouple mitochondrial oxidative phosphorylation. Mechanism is thought to be related to competitive substitution of arsenate for inorganic phosphate, with subsequent formation of unstable arsenate ester that is rapidly hydrolyzed. /Inorganic arsenate/

SYMPTOMS: Symptoms of exposure to this class of compounds may include garlicky odor of the breath and feces, sweetish metallic taste, constriction of the throat, difficulty in swallowing, burning and colicky pains in the esophagus, stomach and bowel; vomiting, profuse and painful diarrhea (feces may become bloody), dehydration with intense thirst; muscular cramps, hematuria, albuminuria, glycosuria, sinus tachycardia and occasionally ventricular arrhythmias; cyanosis, feeble pulse, cold extremities, vertigo, headache, stupor, delirium, mania, syncope, coma, convulsions, general paralysis, ventricular fibrillation, peripheral neuropathy with sensory and motor involvement, severe gastritis or gastroenteritis, weakness, loss of fluid and electrolytes resulting in collapse, shock and death; muscle spasm, encephalopathy, mild gastrointestinal disturbances, anorexia, low-grade fever, pallor, inflammation of the nose, throat, eyes and larynx; stomatitis, salivation, skin afflictions such as erythema, eczema, pigmentation (arsenic melanosis), diffuse alopecia, keratosis (especially of the palms and soles), scaling and desquamation, brittle nails, white lines or bands in the nails (Mees lines), loss of hair and nails, and localized subcutaneous edema (especially of the eyelids); renal damage, hepatomegaly with jaundice (and sometimes pruritis) which may evolve into cirrhosis with ascites; idiopathic portal hypertension with bleeding esophageal varices in chronic poisonings; enteropathy, neonatal death and severe blood dyscrasias. Other symptoms may include cold and clammy skin, fall in blood pressure, circulatory failure, oliguria, anuria, restlessness, nausea, dizziness, chills, irritability, acute pulmonary edema, dyspnea, cough with foamy sputum, rales, polyneuritis, optic neuritis, anesthesias, burning pains in the hands and feet, bronzing of the skin, abdominal cramps, anemia, aplastic anemia and chronic nephritis. Exposure can cause inflammation of the mucous membranes; and irritation, redness and pain of the eyes and skin. Chronic exposure can cause hepatitis and damage to the cardiovascular system, central nervous system, liver and kidneys. Repeated or prolonged contact can result in lesions of the skin and perforation of the nasal septum. It can cause laryngitis, bronchitis, irritation of the nose and throat and unconsciousness. It can also cause nervousness and stomach irritation. Eye contact may result in conjunctivitis. ACUTE/CHRONIC HAZARDS: This compound may be fatal if swallowed, inhaled or absorbed through the skin. It may cause irritation to the skin, eyes, nose and throat. When heated to decomposition it emits toxic fumes of arsenic oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Small doses of inorg arsenic induce mild vasodilation. ... Large doses evoke capillary dilatation; increased capillary permeability may occur in all capillary beds, but it is most pronounced in the splanchnic area. Transudation of plasma may also occur, and the decr in intravascular volume may be significant. Myocardial damage and hypotension appear later. ECG abnormalities may persist for months after recovery from acute intoxication. /Inorganic arsenic/|Chronic exposure to inorg ... arsenicals may cause peripheral ... /neuropathy/ in severe cases, spinal cord may also be involved. After acute ingestion of toxic doses of inorg arsenic, approx 5% of patients have central depression without GI symptoms. ... inorg arsenicals affect bone marrow & alter cellular composition of blood. Hematological evaluation usually reveals anemia with slight-to-moderate leukopenia; eosinophilia may also be present. Anisocytosis becomes evident with incr exposure to arsenic. Vascularity of bone marrow is increased. Some of the chronic hematological effects may result from impaired absorption of folic acid. ... Inorg arsenicals ... are particularly toxic to liver & produce fatty infiltration, central necrosis, & cirrhosis ... Damage may be mild or so severe that death may ensue. Injury is generally to the hepatic parenchyma ... /Arsenic/|Arsenic causes chromosomal breaks in cultured human leukocytes ... There is overwhelming epidemiological evidence that chronic ingestion of arsenic in drinking water ... predisposes to intraepidermal squamous-cell & superficial basal-cell carcinomas of the skin. ... Among metal workers, there is strong correlation between intensity & duration of exposure to arsenic & lung cancer. ... /acute poisoning effects:/ Oliguria with proteinuria and hematuria is usually present; eventually anuria may occur. ... As loss of fluid proceeds, symptoms of shock appear. Hypoxic convulsions may occur terminally, & coma & death ensue. In severe poisoning, death can occur within an hr, but the usual interval is 24 hr. /Arsenic/|Most common early signs of chronic arsenic poisoning are ... garlic odor of breath & perspiration, excessive salivation & sweating, stomatitis ... /other chronic effects incl/ ... generalized itching, sore throat, coryza, lacrimation, numbness, burning or tingling of extremities, dermatitis, vitiligo, & alopecia. ... Bone marrow is seriously injured by arsenic. With severe exposure, all hematological elements may be affected. /Arsenic/|For more Human Toxicity Excerpts (Complete) data for DISODIUM ARSENATE HEPTAHYDRATE (8 total), please visit the HSDB record page.

arsenic acid (H3AsO4), sodium salt (1:3)

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Cough. Headache. Sore throat. Weakness. Further see Ingestion.

Redness. Pain.

Redness. Pain.

The salt of commerce is about 99% pure /sodium arsenate, dibasic/

Dibasic sodium arsenate ... contains 40% arsenic when anhydrous or 24% in the case of the usual hydrate

Analyte: trace metals; matrix: air; procedure: filter collection, acid digestion, atomic absorption spectrophotometry; Range: 10-50 ug/ml; 420-2100 ug/cu m. /Trace metals/|Analyte: Arsenic; matrix: air; range: 0.05-2.0 ug/sample; procedure: filter/arsine generation, (AAS) atomic absorption spectrometry; arsenic; precision: 10.7% RSD (analytical) /Arsenic/|Analyte: arsenic; matrix: air; range 1.0-25 ug/sample; procedure: arsine generation-colorimetric; precision: 4-9% average deviation /Arsenic/|Analyte: Arsenic, matrix: air, procedure: filter collection, acid digestion, ICP-AES (inductively coupled plasma-atomic emission spectroscopy) analysis, range: 5-2000 ug/cu m, precision: 13 ng/ml detection limit. /Arsenic/|For more Analytic Laboratory Methods (Complete) data for DISODIUM ARSENATE HEPTAHYDRATE (6 total), please visit the HSDB record page.