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Nisoxetine

Nisoxetine structure

CAS No:
53179-07-0
Formula:
C17H21NO2
Chemical Name:
Nisoxetine
Synonyms:
Benzenepropanamine,γ-(2-methoxyphenoxy)-N-methyl-;Benzenepropanamine,γ-(2-methoxyphenoxy)-N-methyl-,(±)-;γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine;dl-3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine;Nisoxetine;Compound 89218;NSC 283481;[3-(2-Methoxy-phenoxy)-3-phenyl-propyl]-methyl-amine;57226-61-6
Categories:
Organic Chemistry > Amides

Description

Nisoxetine is a secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group. It has a role as an antidepressant and an adrenergic uptake inhibitor. It is an aromatic ether and a secondary amino compound.|Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.

Nisoxetine Basic Attributes

Molecular Weight：

271.35400

Exact Mass：

271.35

NSC Number：

283481

DSSTox ID：

DTXSID0045175

HScode：

2922299090

Characteristics

PSA：

30.49000

XLogP3：

3.81570

Density：

1.054g/cm3

Boiling Point：

404.8ºC

Flash Point：

170.6ºC

Refractive Index：

1.547

Drug Information

MeSH Entry Terms：

3-(2-methoxyphenoxy)-N-methyl-3-phenylpropylamine

Computed Properties

Molecular Weight:271.35
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:271.157228913
Monoisotopic Mass:271.157228913
Topological Polar Surface Area:30.5
Heavy Atom Count:20
Complexity:253
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes