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trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride structure

CAS No:
67198-13-4
Formula:
C19H26Cl2N2O
Chemical Name:
trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride
Synonyms:
Benzeneacetamide,3,4-dichloro-N-methyl-N-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]-,rel-;Benzeneacetamide,3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-,trans-;rel-3,4-Dichloro-N-methyl-N-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide;U 50488;UM 1382;NIH 10533;(±)-trans-U 50488;trans-U 50488;83913-05-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

2-(3,4-dichlorophenyl)-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]acetamide is a member of acetamides.|A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Basic Attributes

Molecular Weight：

465.43400

Exact Mass：

369.33

DSSTox ID：

DTXSID10600858

Characteristics

PSA：

86.30000

XLogP3：

4.92400

Density：

1.23g/cm3

Boiling Point：

496.6ºC

Flash Point：

254.1ºC

Refractive Index：

1.587

Drug Information

MeSH：

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer

Computed Properties

Molecular Weight:369.3
XLogP3:4.4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:368.1422188
Monoisotopic Mass:368.1422188
Topological Polar Surface Area:23.6
Heavy Atom Count:24
Complexity:428
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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67198-13-4

CAS No.: 67198-13-4

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Guide of trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride

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