1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea
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![1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/139f289fde8a4157af61654328c00f6a.png "1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea")
1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea
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CAS No:
154355-76-7
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Formula:
C16H15FN2O2S
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Chemical Name:
1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea
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Synonyms:
1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea;Atreleuton-d4;(R)-N-(3-(5-(4-Fluorophenylmethyl)thien-2-yl)-1-methyl-2-propynyl)-N-hydroxyurea;A8576;VIA-2291;Urea, N-[(1R)-3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-;Atreleuton >=98% (HPLC)
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CAS No:
Description
Atreleuton has been used in trials studying the treatment of Atherosclerosis and Coronary Artery Disease.
1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea Basic Attributes
318.37
318.37
U301T88E1M
DTXSID10165598
white to beige
Characteristics
95.79000
3.50170
1.37±0.1 g/cm3(Predicted)
506.7±60.0 °C(Predicted)
260.2ºC
1.652
4.34E-11mmHg at 25°C
9.63±0.50(Predicted)
2-8°C
Safety Information
3
Xn
22
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES. (See all compounds classified as Lipoxygenase Inhibitors.)
ABT 761
1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea Use and Manufacturing
Anti-asthmatic; inhibitor (5-lipoxygenase).
Computed Properties
Molecular Weight:318.4
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:318.08382706
Monoisotopic Mass:318.08382706
Topological Polar Surface Area:94.8
Heavy Atom Count:22
Complexity:454
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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