Nafadotride
-
Nafadotride
structure -
-
CAS No:
149649-22-9
-
Formula:
C22H27N3O2
-
Chemical Name:
Nafadotride
-
Synonyms:
2-Naphthalenecarboxamide,N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-;N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide;Nafadotride
-
CAS No:
Description
Nafadotride is a naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration. It has a role as a dopaminergic antagonist. It is a tertiary amino compound, a nitrile, a naphthalenecarboxamide, a member of pyrrolidines and an aromatic ether.
Drug Information
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)
N-(((2s)-1-butylpyrrolidin-2-yl)methyl)-4-cyano-1-methoxy-2-naphthamide
Computed Properties
Molecular Weight:365.5
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:365.21032711
Monoisotopic Mass:365.21032711
Topological Polar Surface Area:65.4
Heavy Atom Count:27
Complexity:543
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Request for Quotation