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Home > Encyclopedia > S(+)-Niguldipine hydrochloride

S(+)-Niguldipine hydrochloride

S(+)-Niguldipine hydrochloride structure

S(+)-Niguldipine hydrochloride 

structure
  • CAS No:

    113165-32-5

  • Formula:

    C36H39N3O6

  • Chemical Name:

    S(+)-Niguldipine hydrochloride

  • Synonyms:

    (S)-(+)-Niguldipine hydrochloride,(S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid,3-(4,4-diphenyl-1-piperidinyl)propylmethylesterhydrochloride;

Description

(4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-[3-(4,4-diphenyl-1-piperidinyl)propyl] ester O3-methyl ester is a diarylmethane.|Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.

S(+)-Niguldipine hydrochloride Basic Attributes

609.71100

609.28388597 g/mol

Z81N45O25Z

DTXSID60274008

Characteristics

113.69000

6.80790

1.205g/cm3

729.5ºC

395ºC

1.589

-20ºC

3.9E-21mmHg at 25°C

Safety Information

3

Drug Information

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

3-((4,4-diphenyl-1-piperidinyl)propyl)-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride

Computed Properties

Molecular Weight:609.7
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:11
Exact Mass:609.28388597
Monoisotopic Mass:609.28388597
Topological Polar Surface Area:114
Heavy Atom Count:45
Complexity:1100
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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