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Acotiamide

Acotiamide structure

CAS No:
185106-16-5
Formula:
C21H30N4O5S
Chemical Name:
Acotiamide
Synonyms:
4-Thiazolecarboxamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide;Acotiamide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Acotiamide is a member of salicylamides.|Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.|Acotiamide is a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Acotiamide Basic Attributes

Molecular Weight：

450.55200

Exact Mass：

450.55

UNII：

D42OWK5383

NCI Thesaurus Code：

C65214

Characteristics

PSA：

148.24000

XLogP3：

3.92560

Density：

1.246g/cm3

Refractive Index：

1.591

Drug Information

Drug Indication：

Treatment of functional dyspepsia

MeSH：

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)|Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

MeSH Entry Terms：

acotiamide

Acotiamide Use and Manufacturing

Use Classification：

Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:450.6
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:450.19369124
Monoisotopic Mass:450.19369124
Topological Polar Surface Area:141
Heavy Atom Count:31
Complexity:586
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Acotiamide Hydrochloride

CAS No.: 185106-16-5

Content: 99.00%

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